Phosphonoacetic acid
Based on 2 publication(s) in Google Scholar
Phosphonoacetic acid is an endogenous metabolite and antiviral agent. Phosphonoacetic acid is active against orthopoxviruses and herpes viruses. Phosphonoacetic acid can inhibit HSV DNA synthesis and virus-specific DNA polymerase activity, and affect the synthesis of late viral proteins.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 4408-78-0
- Formula: C2H5O5P
- Molecular Weight:140.03
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Phosphonoacetic acid
MoreAll Endogenous Metabolite Isoforms
MoreAll DNA/RNA Synthesis Isoforms
More
Biological Activity
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DNA Polymerase |
Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
3500 μM
Compound: Phosphonoacetic acid (PAA)
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In vitro cytotoxic concentration in vero cells.
In vitro cytotoxic concentration in vero cells.
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[PMID: 14584951] |
| Vero | ED50 |
240 μM
Compound: Phosphonoacetic acid (PAA)
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Inhibitory activity against HSV-1 in vero cells
Inhibitory activity against HSV-1 in vero cells
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[PMID: 14584951] |
Phosphonoacetic acid (≥200 μg/mL; 24 h) inhibits viral growth and DNA synthesis in HSV-1-infected BHK-21 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4408-78-0
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Appearance Solid
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Molecular Weight 140.03
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Formula C2H5O5P
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Color White to off-white
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SMILES
O=C(O)CP(O)(O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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PLoS Pathog
Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. [Abstract]2026 Jan 26;22(1):e1013903. PMID: 41587213 -
J Virol
Pseudorabies virus infection triggers mitophagy to dampen the interferon response and promote viral replication. [Abstract]2024 Oct 22;98(10):e0104824. PMID: 39212384
Solvent & Solubility
H2O : 260 mg/mL (1856.74 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (714.13 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (273 KB)
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SDS (477 KB)
- English - EN (477 KB)
- Français - FR (477 KB)
- Deutsch - DE (477 KB)
- Norwegian - NO (477 KB)
- Español - ES (477 KB)
- Swedish - SV (477 KB)
- Italian - IT (477 KB)
- Portuguese - PT (477 KB)
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Handling Instructions (2659 KB)
References
[1]. Honess RW, et al. Herpes simplex virus resistance and sensitivity to phosphonoacetic acid. J Virol. 1977 Feb;21(2):584-600. [Content Brief]
[2]. Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.1413 mL | 35.7066 mL | 71.4133 mL | 178.5332 mL |
| 5 mM | 1.4283 mL | 7.1413 mL | 14.2827 mL | 35.7066 mL | |
| 10 mM | 0.7141 mL | 3.5707 mL | 7.1413 mL | 17.8533 mL | |
| 15 mM | 0.4761 mL | 2.3804 mL | 4.7609 mL | 11.9022 mL | |
| 20 mM | 0.3571 mL | 1.7853 mL | 3.5707 mL | 8.9267 mL | |
| 25 mM | 0.2857 mL | 1.4283 mL | 2.8565 mL | 7.1413 mL | |
| 30 mM | 0.2380 mL | 1.1902 mL | 2.3804 mL | 5.9511 mL | |
| 40 mM | 0.1785 mL | 0.8927 mL | 1.7853 mL | 4.4633 mL | |
| 50 mM | 0.1428 mL | 0.7141 mL | 1.4283 mL | 3.5707 mL | |
| 60 mM | 0.1190 mL | 0.5951 mL | 1.1902 mL | 2.9756 mL | |
| 80 mM | 0.0893 mL | 0.4463 mL | 0.8927 mL | 2.2317 mL | |
| 100 mM | 0.0714 mL | 0.3571 mL | 0.7141 mL | 1.7853 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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