Phosphonoacetic acid sodium
Based on 3 publication(s) in Google Scholar
Phosphonoacetic acid sodium is a potent antiviral agent. Phosphonoacetic acid sodium inhibits a variety of herpesviruses, orthopoxviruses, and retroviruses. Phosphonoacetic acid sodium strongly inhibits viral and cellular DNA polymerase, reverse transcriptase, and terminal deoxynucleotidyl transferase activities in a non-competitive or uncompetitive manner by binding to the pyrophosphate site of the enzyme. Phosphonoacetic acid sodium is useful for research related to lymphoid leukemia, herpesvirus infection, and vaccinia virus skin lesions.
For research use only. We do not sell to patients.
- CAS No.: 36983-81-0
- Formula: C2H3Na2O5P
- Molecular Weight:184.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Phosphonoacetic acid sodium
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Biological Activity
Description
IC50 & Target
[1]|
HSV-1 |
DNA Polymerases |
In Vitro
Phosphonoacetic acid (1 h) sodium inhibits purified DNA polymerases α, β, and γ from L1210 cells, HSV-induced DNA polymerase, SSV reverse transcriptase, L1210 C-type virus reverse transcriptase, and terminal deoxynucleotidyl transferase from acute lymphoblastic leukemia leukocytes, with the strongest inhibitory potency observed against L1210 DNA polymerase α and HSV-induced DNA polymerase (IC50 ≈ 25 μM)[1].
Phosphonoacetic acid (0.5 mM; 15-60 min) sodium transiently and time-dependently inhibits DNA polymerase α and β in L1210 cells[1].
Phosphonoacetic acid (50-200 μg/mL; 1-6 days) sodium inhibits cell growth and C-type virus production in the mouse lymphoid leukemia cell line L1210[1].
Phosphonoacetic acid (14.3-357 μM; 1-6 days) sodium dose-dependently inhibits HHV-6 infection in cord blood mononuclear cells, with near-complete inhibition achieved at a concentration of 71.4 μM (10 μg/mL)[2].
Phosphonoacetic acid (14.3-357 μM; 90 min) sodium inhibits HHV-6-specific DNA polymerase activity in in vitro enzymatic assays[2].
Phosphonoacetic acid (24 h) sodium exhibits an inhibitory effect on HSV-1 infection in BHK-21 cells [3].
Phosphonoacetic acid (50-500 μg/mL; 20-75 h) sodium exhibits an inhibitory effect on cell growth in uninfected BHK-21 cells[3].
Phosphonoacetic acid (50-500 μg/mL; up to 18 h) sodium inhibits the growth of herpes simplex virus (sensitive and resistant strains) in BHK-21 cells, and this effect depends on the time of drug addition[3].
Phosphonoacetic acid (50-200 μg/mL) sodium has a role in determining the percentage of surviving plaques for screening and assaying PAA-resistant HSV-1 variants in BHK-21 cells[3].
Phosphonoacetic acid (up to 50 μg/mL; 60 min) sodium inhibits the virus-specific DNA polymerase activity of PAA-sensitive HSV-1 in in vitro biochemical reactions, but does not inhibit PAA-resistant mutant strains[3].
Phosphonoacetic acid sodium (50 μg/mL-1.0 mg/mL; radiolabeling 1.5-22 h) selectively inhibits late (γ) viral protein synthesis of HSV-1-sensitive strains in HEp-2 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L1210 (V) murine lymphoid leukemia cells (producers of type C virus)
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Concentration:50, 100, 200 μg/mL
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Incubation Time:1, 2, 3, 4, 5, 6 days
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Result:Had no noticeable effect on L1210 cell growth but inhibited type C virus production by more than 50% on day 3 (while cell growth was only reduced by 16%) at 50 μg/mL.
Reduced L1210 cell growth considerably at 100 μg/mL and 200 μg/mL, with a more profound inhibitory effect on type C virus production than on cell growth at all concentrations tested above 50 μg/mL.
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Cell Line:Uninfected BHK-21 cells
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Concentration:50, 100, 150, 200, 500 μg/ml
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Incubation Time:75 h
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Result:Reduced the cell growth rate, and cell division was completely inhibited at higher concentrations.
In Vivo
Chemical Information
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CAS No. 36983-81-0
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Molecular Weight 184.00
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Formula C2H3Na2O5P
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SMILES
O=C(CP(O[Na])(O[Na])=O)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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PLoS Pathog
Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. [Abstract]2026 Jan 26;22(1):e1013903. PMID: 41587213 -
Microbiol Spectr
2026 Jun 2;14(6):e0160825. PMID: 41995456 -
J Virol
Pseudorabies virus infection triggers mitophagy to dampen the interferon response and promote viral replication. [Abstract]2024 Oct 22;98(10):e0104824. PMID: 39212384
Purity & Documentation
References
[3]. Honess RW, et al. Herpes simplex virus resistance and sensitivity to phosphonoacetic acid. Journal of virology. 1977 Feb;21(2):584-600. [Content Brief]
[4]. Smee DF, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral research. 2003 Jan;57(1-2):41-52. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phosphonoacetic acid sodium Related Classifications
HY-128744A Related Classifications
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