Phosphonoacetic acid sodium
Based on 3 publication(s) in Google Scholar
Phosphonoacetic acid sodium is a potent antiviral agent. Phosphonoacetic acid sodium inhibits a variety of herpesviruses, orthopoxviruses, and retroviruses. Phosphonoacetic acid sodium strongly inhibits viral and cellular DNA polymerase, reverse transcriptase, and terminal deoxynucleotidyl transferase activities in a non-competitive or uncompetitive manner by binding to the pyrophosphate site of the enzyme. Phosphonoacetic acid sodium is useful for research related to lymphoid leukemia, herpesvirus infection, and vaccinia virus skin lesions.
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- CAS No.: 36983-81-0
- Formule: C2H3Na2O5P
- Masse moléculaire:184.00
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Stockage:
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Other In-stock Forms of Phosphonoacetic acid sodium
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) Phosphonoacetic acid sodium
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Activité biologique
Description
IC50 & Target
[1]|
HSV-1 |
DNA Polymerases |
In Vitro
Phosphonoacetic acid (14.3-357 μM; 90 min) sodium inhibits HHV-6-specific DNA polymerase activity in in vitro enzymatic assays[2].
Phosphonoacetic acid (24 h) sodium exhibits an inhibitory effect on HSV-1 infection in BHK-21 cells [3].
Phosphonoacetic acid (50-500 μg/mL; 20-75 h) sodium exhibits an inhibitory effect on cell growth in uninfected BHK-21 cells[3].
Phosphonoacetic acid (50-500 μg/mL; up to 18 h) sodium inhibits the growth of herpes simplex virus (sensitive and resistant strains) in BHK-21 cells, and this effect depends on the time of drug addition[3].
Phosphonoacetic acid (50-200 μg/mL) sodium has a role in determining the percentage of surviving plaques for screening and assaying PAA-resistant HSV-1 variants in BHK-21 cells[3].
Phosphonoacetic acid (up to 50 μg/mL; 60 min) sodium inhibits the virus-specific DNA polymerase activity of PAA-sensitive HSV-1 in in vitro biochemical reactions, but does not inhibit PAA-resistant mutant strains[3].
Phosphonoacetic acid (50 μg/mL-1.0 mg/mL; radiolabeling 1.5-22 h) sodium selectively inhibits late (γ) viral protein synthesis of HSV-1-sensitive strains in HEp-2 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L1210 (V) murine lymphoid leukemia cells (producers of type C virus)
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Concentration:50, 100, 200 μg/mL
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Incubation Time:1, 2, 3, 4, 5, 6 days
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Result:Had no noticeable effect on L1210 cell growth but inhibited type C virus production by more than 50% on day 3 (while cell growth was only reduced by 16%) at 50 μg/mL.
Reduced L1210 cell growth considerably at 100 μg/mL and 200 μg/mL, with a more profound inhibitory effect on type C virus production than on cell growth at all concentrations tested above 50 μg/mL.
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Cell Line:Uninfected BHK-21 cells
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Concentration:50, 100, 150, 200, 500 μg/ml
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Incubation Time:75 h
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Result:Reduced the cell growth rate, and cell division was completely inhibited at higher concentrations.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 36983-81-0
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Masse moléculaire 184.00
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Formule C2H3Na2O5P
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SMILES
O=C(CP(O[Na])(O[Na])=O)O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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PLoS Pathog
Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. [Abstract]2026 Jan 26;22(1):e1013903. PMID: 41587213 -
Microbiol Spectr
2026 Jun 2;14(6):e0160825. PMID: 41995456 -
J Virol
Pseudorabies virus infection triggers mitophagy to dampen the interferon response and promote viral replication. [Abstract]2024 Oct 22;98(10):e0104824. PMID: 39212384
Pureté et documentation
Références
[3]. Honess RW, et al. Herpes simplex virus resistance and sensitivity to phosphonoacetic acid. Journal of virology. 1977 Feb;21(2):584-600. [Content Brief]
[4]. Smee DF, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral research. 2003 Jan;57(1-2):41-52. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phosphonoacetic acid sodium Related Classifications
HY-128744A Related Classifications
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Keywords
- Phosphonoacetic acid
- 36983-81-0
- HSV
- Orthopoxvirus
- DNA/RNA Synthesis
- Reverse Transcriptase
- Herpes simplex virus
- viral DNA replication
- reverse transcriptase
- herpesvirus
- HHV-6
- BHK-21 cells
- mouse L1210 cell
- human terminal deoxynucleotidyltransferase
- cord blood mononuclear cell
- lymphoid leukemia
- DNA polymerase
- Inhibitor
- inhibitor
- inhibit