36983-81-0
Chemical Structure
Phosphonoacetic acid sodium
- CAS No.: 36983-81-0
- Formula:C2H3Na2O5P
- Molecular Weight:184.00
IUPAC Name: (1R,2S,5R)-7-oxo-2-(2-((S)-pyrrolidine-3-carbonyl)hydrazine-1-carbonyl)-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate
InChIKey: JBIQZGVFCHTYBY-UHFFFAOYSA-L
SMILES: O=C(CP(O[Na])(O[Na])=O)O
Biological Activity: Phosphonoacetic acid sodium is a potent antiviral agent. Phosphonoacetic acid sodium inhibits a variety of herpesviruses, orthopoxviruses, and retroviruses. Phosphonoacetic acid sodium strongly inhibits viral and cellular DNA polymerase, reverse transcriptase, and terminal deoxynucleotidyl transferase activities in a non-competitive or uncompetitive manner by binding to the pyrophosphate site of the enzyme. Phosphonoacetic acid sodium is useful for research related to lymphoid leukemia, herpesvirus infection, and vaccinia virus skin lesions[1][2][3][4].
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Phosphonoacetic acid sodium | Phosphonoacetic acid sodium is a potent antiviral agent. Phosphonoacetic acid sodium inhibits a variety of herpesviruses, orthopoxviruses, and retroviruses. Phosphonoacetic acid sodium strongly inhibits viral and cellular DNA polymerase, reverse transcriptase, and terminal deoxynucleotidyl transferase activities in a non-competitive or uncompetitive manner by binding to the pyrophosphate site of the enzyme. Phosphonoacetic acid sodium is useful for research related to lymphoid leukemia, herpesvirus infection, and vaccinia virus skin lesions. | |||||||||||||||||||||
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References
- [1]. Allaudeen HS, et al. Inhibition of activities of DNA polymerase alpha, beta, gamma, and reverse transcriptase of L1210 cells by phosphonoacetic acid. Biochim Biophys Acta. 1978 Oct 24;520(3):490-7.
- [2]. Shiraki K, et al. Phosphonoacetic acid inhibits replication of human herpesvirus-6. Antiviral Res. 1989 Dec;12(5-6):311-8.
- [3]. Honess RW, et al. Herpes simplex virus resistance and sensitivity to phosphonoacetic acid. Journal of virology. 1977 Feb;21(2):584-600. [Content Brief]
- [4]. Smee DF, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral research. 2003 Jan;57(1-2):41-52. [Content Brief]
