4408-78-0
Chemical Structure
Phosphonoacetic acid
- CAS No.: 4408-78-0
- Formula:C2H5O5P
- Molecular Weight:140.03
IUPAC Name: 2-phosphonoacetic acid
InChIKey: XUYJLQHKOGNDPB-UHFFFAOYSA-N
SMILES: O=C(O)CP(O)(O)=O
Biological Activity: Phosphonoacetic acid is a potent antiviral agent. Phosphonoacetic acid inhibits a variety of herpesviruses, orthopoxviruses, and retroviruses. Phosphonoacetic acid strongly inhibits viral and cellular DNA polymerase, reverse transcriptase, and terminal deoxynucleotidyl transferase activities in a non-competitive or uncompetitive manner by binding to the pyrophosphate site of the enzyme. Phosphonoacetic acid is useful for research related to lymphoid leukemia, herpesvirus infection, and vaccinia virus skin lesions[1][2][3][4].
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Phosphonoacetic acid | 98.0% | Phosphonoacetic acid is a potent antiviral agent. Phosphonoacetic acid inhibits a variety of herpesviruses, orthopoxviruses, and retroviruses. Phosphonoacetic acid strongly inhibits viral and cellular DNA polymerase, reverse transcriptase, and terminal deoxynucleotidyl transferase activities in a non-competitive or uncompetitive manner by binding to the pyrophosphate site of the enzyme. Phosphonoacetic acid is useful for research related to lymphoid leukemia, herpesvirus infection, and vaccinia virus skin lesions. | ||||||||||||||||||||
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Phosphonoacetic acid (Standard) | ≥98% | Phosphonoacetic acid Standard is the analytical standard of Phosphonoacetic acid (HY-128744). This product is intended for research and analytical applications. Phosphonoacetic acid is a potent antiviral agent. Phosphonoacetic acid inhibits a variety of herpesviruses, orthopoxviruses, and retroviruses. Phosphonoacetic acid strongly inhibits viral and cellular DNA polymerase, reverse transcriptase, and terminal deoxynucleotidyl transferase activities in a non-competitive or uncompetitive manner by binding to the pyrophosphate site of the enzyme. Phosphonoacetic acid is useful for research related to lymphoid leukemia, herpesvirus infection, and vaccinia virus skin lesions. | ||||||||||||||||||||
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References
- [1]. Allaudeen HS, et al. Inhibition of activities of DNA polymerase alpha, beta, gamma, and reverse transcriptase of L1210 cells by phosphonoacetic acid. Biochim Biophys Acta. 1978 Oct 24;520(3):490-7.
- [2]. Shiraki K, et al. Phosphonoacetic acid inhibits replication of human herpesvirus-6. Antiviral Res. 1989 Dec;12(5-6):311-8.
- [3]. Honess RW, et al. Herpes simplex virus resistance and sensitivity to phosphonoacetic acid. Journal of virology. 1977 Feb;21(2):584-600. [Content Brief]
- [4]. Smee DF, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral research. 2003 Jan;57(1-2):41-52. [Content Brief]
