2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. 1'-Hydroxy bufuralol

1'-Hydroxy bufuralol  (Synonyms: Ro 03-7410)

Cat. No.: HY-122277 Purity: 96.62%
COA
SDS
Handling Instructions Technical Support

1'-Hydroxy bufuralol is the main metabolite of Bufuralol (HY-105124) by the cytochrome P450 isoenzymes 2D1 and 2D2 (CYP2D1/2). 1'-Hydroxy bufuralol can be used to determine CYP2D1/2 enzyme activity.

For research use only. We do not sell to patients.

1'-Hydroxy bufuralol

1'-Hydroxy bufuralol Chemical Structure

CAS No. : 57704-16-2

Size Price Stock Quantity
1 mg In-stock
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 1'-Hydroxy bufuralol:

1'-Hydroxy bufuralol Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

1'-Hydroxy bufuralol is the main metabolite of Bufuralol (HY-105124) by the cytochrome P450 isoenzymes 2D1 and 2D2 (CYP2D1/2). 1'-Hydroxy bufuralol can be used to determine CYP2D1/2 enzyme activity[1][2].

IC50 & Target

CYP2

 

In Vitro

Bufuralol is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1'-Hydroxy bufuralol Related Antibodies
Molecular Weight

277.36

Formula

C16H23NO3
CAS No.
Appearance

<41°C Solid,>49°C Liquid

Color

Off-white to light yellow

SMILES

CC(C1=C2OC(C(CNC(C)(C)C)O)=CC2=CC=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (251 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

1'-Hydroxy bufuralol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1'-Hydroxy bufuralol57704-16-2Ro 03-7410Drug MetaboliteInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
1'-Hydroxy bufuralol
Cat. No.:
HY-122277
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.