57704-16-2
57704-16-2
Chemical Structure
1'-Hydroxy bufuralol
Synonym(s): Ro 03-7410
- CAS No.: 57704-16-2
- Formula:C16H23NO3
- Molecular Weight:277.36
IUPAC Name: 2-(tert-butylamino)-1-(7-(1-hydroxyethyl)benzofuran-2-yl)ethan-1-ol
InChIKey: GTYMTYBCXVOBBB-UHFFFAOYSA-N
SMILES: CC(C1=C2OC(C(CNC(C)(C)C)O)=CC2=CC=C1)O
Biological Activity: 1'-Hydroxy bufuralol is the main metabolite of Bufuralol (HY-105124) by the cytochrome P450 isoenzymes 2D1 and 2D2 (CYP2D1/2). 1'-Hydroxy bufuralol can be used to determine CYP2D1/2 enzyme activity[1][2].
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1'-Hydroxy bufuralol | 96.62% | 1'-Hydroxy bufuralol is the main metabolite of Bufuralol (HY-105124) by the cytochrome P450 isoenzymes 2D1 and 2D2 (CYP2D1/2). 1'-Hydroxy bufuralol can be used to determine CYP2D1/2 enzyme activity. | ||||||||||||||||||||
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1'-Hydroxy bufuralol-d9 | 99.9% | 1'-Hydroxy bufuralol-d9 is a deuterium labeled 1'-Hydroxy bufuralol (HY-122277). 1'-Hydroxy bufuralol is the main metabolite of Bufuralol (HY-105124) by the cytochrome P450 isoenzymes 2D1 and 2D2 (CYP2D1/2). 1'-Hydroxy bufuralol can be used to determine CYP2D1/2 enzyme activity. | ||||||||||||||||||||
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References
- [1]. Evangelos P Daskalopoulos, et al. D₂-dopaminergic receptor-linked pathways: critical regulators of CYP3A, CYP2C, and CYP2D. Mol Pharmacol. 2012 Oct;82(4):668-78. [Content Brief]
- [2]. H Yamazaki, et al. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. Mol Pharmacol. 1994 Sep;46(3):568-77. [Content Brief]
