Tulobuterol-d9 hydrochloride
Based on 1 Customer Validation
Tulobuterol-d9 (hydrochloride) is the deuterium labeled Tulobuterol. Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 1325559-14-5
- Formula: C12H10D9Cl2NO
- Molecular Weight:273.25
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1325559-14-5
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Unlabeled Cas 41570-61-0
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Appearance Solid
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Molecular Weight 273.25
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Formula C12H10D9Cl2NO
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Color White to off-white
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SMILES
[2H]C(C(NCC(O)C1=CC=CC=C1Cl)(C([2H])([2H])[2H])C([2H])([2H])[2H])([2H])[2H].[H]Cl
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Synonyms
C-78-d9
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (365.97 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Yamaya M, et al. Tulobuterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Physiol Rep. 2013 Aug;1(3):e00041.;Shindoh C, et al. Tulobuterol patch maintains diaphragm muscle contractility for over twenty-four hours in a mouse model of sepsis. Tohoku J Exp Med. 2009 Aug;218(4):271-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.6597 mL | 18.2983 mL | 36.5965 mL | 91.4913 mL |
| 5 mM | 0.7319 mL | 3.6597 mL | 7.3193 mL | 18.2983 mL | |
| 10 mM | 0.3660 mL | 1.8298 mL | 3.6597 mL | 9.1491 mL | |
| 15 mM | 0.2440 mL | 1.2199 mL | 2.4398 mL | 6.0994 mL | |
| 20 mM | 0.1830 mL | 0.9149 mL | 1.8298 mL | 4.5746 mL | |
| 25 mM | 0.1464 mL | 0.7319 mL | 1.4639 mL | 3.6597 mL | |
| 30 mM | 0.1220 mL | 0.6099 mL | 1.2199 mL | 3.0497 mL | |
| 40 mM | 0.0915 mL | 0.4575 mL | 0.9149 mL | 2.2873 mL | |
| 50 mM | 0.0732 mL | 0.3660 mL | 0.7319 mL | 1.8298 mL | |
| 60 mM | 0.0610 mL | 0.3050 mL | 0.6099 mL | 1.5249 mL | |
| 80 mM | 0.0457 mL | 0.2287 mL | 0.4575 mL | 1.1436 mL | |
| 100 mM | 0.0366 mL | 0.1830 mL | 0.3660 mL | 0.9149 mL |
Tulobuterol-d9 hydrochloride Related Classifications
HY-B1810S Related Classifications
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