2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Bufuralol hydrochloride

Bufuralol hydrochloride  (Synonyms: Ro 3-4787 hydrochloride)

Cat. No.: HY-105124A Purity: 98.01%
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Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate.

For research use only. We do not sell to patients.

Bufuralol hydrochloride Chemical Structure

Bufuralol hydrochloride Chemical Structure

CAS No. : 60398-91-6

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1 mg USD 285 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Bufuralol hydrochloride:

Bufuralol hydrochloride Related Antibodies

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1 Publications Citing Use of MCE Bufuralol hydrochloride

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α adrenergic receptor β adrenergic receptor

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate[1][2].

IC50 & Target[1]

β adrenergic receptor

 

In Vitro

Bufuralol (Ro 3-4787) hydrochloride is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bufuralol hydrochloride Related Antibodies
In Vivo

Bufuralol (Ro 3-4787) hydrochloride metabolism mediated by NADPH exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

297.82

Formula

C16H24ClNO2
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

OC(CNC(C)(C)C)C1=CC2=CC=CC(CC)=C2O1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Ethanol : 15 mg/mL (50.37 mM; Need ultrasonic and warming)

DMSO : 10 mg/mL (33.58 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3577 mL 16.7887 mL 33.5773 mL
5 mM 0.6715 mL 3.3577 mL 6.7155 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 3.3577 mL 16.7887 mL 33.5773 mL 83.9433 mL
5 mM 0.6715 mL 3.3577 mL 6.7155 mL 16.7887 mL
10 mM 0.3358 mL 1.6789 mL 3.3577 mL 8.3943 mL
15 mM 0.2238 mL 1.1192 mL 2.2385 mL 5.5962 mL
20 mM 0.1679 mL 0.8394 mL 1.6789 mL 4.1972 mL
25 mM 0.1343 mL 0.6715 mL 1.3431 mL 3.3577 mL
30 mM 0.1119 mL 0.5596 mL 1.1192 mL 2.7981 mL
Ethanol 40 mM 0.0839 mL 0.4197 mL 0.8394 mL 2.0986 mL
50 mM 0.0672 mL 0.3358 mL 0.6715 mL 1.6789 mL
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Bufuralol hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bufuralol60398-91-6Ro 3-4787Adrenergic ReceptorBeta ReceptorCYP2D6probesubstratenon-selectiveorallyβ-adrenoreceptorInhibitorinhibitorinhibit

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