1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Bufuralol hydrochloride

Bufuralol hydrochloride (Synonyms: Ro 3-4787 hydrochloride)

Cat. No.: HY-105124A
Handling Instructions

Bufuralol hydrochloride (Ro 3-4787 hydrochloride) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate.

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Bufuralol hydrochloride Chemical Structure

Bufuralol hydrochloride Chemical Structure

CAS No. : 60398-91-6

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Description

Bufuralol hydrochloride (Ro 3-4787 hydrochloride) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate[1][2].

In Vitro

Bufuralol is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates[3].

In Vivo

Bufuralol metabolism mediated by NADPH exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers[4].

Molecular Weight

297.82

Formula

C₁₆H₂₄ClNO₂

CAS No.

60398-91-6

SMILES

OC(CNC(C)(C)C)C1=CC2=CC=CC(CC)=C2O1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BufuralolRo 3-4787Adrenergic ReceptorBeta ReceptorCYP2D6probesubstratenon-selectiveorallyβ-adrenoreceptorInhibitorinhibitorinhibit

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Bufuralol hydrochloride
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