60398-91-6
60398-91-6
Chemical Structure
Bufuralol hydrochloride
Synonym(s): Ro 3-4787 hydrochloride
- CAS No.: 60398-91-6
- Formula:C16H24ClNO2
- Molecular Weight:297.82
IUPAC Name: 2-(tert-butylamino)-1-(7-ethylbenzofuran-2-yl)ethan-1-ol hydrochloride
InChIKey: KJBONRGCLLBWCJ-UHFFFAOYSA-N
SMILES: OC(CNC(C)(C)C)C1=CC2=CC=CC(CC)=C2O1.[H]Cl
Biological Activity: Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate[1][2].
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Bufuralol hydrochloride | 98.56% | Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate. | ||||||||||||||||||||
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Bufuralol hydrochloride (Standard) | ≥98% | Bufuralol (hydrochloride) (Standard) is the analytical standard of Bufuralol (hydrochloride). This product is intended for research and analytical applications. Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate. | ||||||||||||||||||||
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References
- [1]. T H Pringle, et al. Pharmacodynamic and pharmacokinetic studies on bufuralol in man. Br J Clin Pharmacol. 1986 Nov;22(5):527-34. [Content Brief]
- [2]. Jie Cai, et al. Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro. Basic Clin Pharmacol Toxicol. 2016 Mar;118(3):190-9. [Content Brief]
