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Cat. No.: HY-P1319

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Nociceptin(1-7)

Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL₁ (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo.

For research use only. We do not sell to patients.

CAS No.: 178249-42-8
Formula: C₃₁H₄₁N₇O₉
Molecular Weight:655.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nociceptin(1-7) Chemical Structure

CAS No.: 178249-42-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

NOP Receptor/ORL1

All Opioid Receptor Isoforms :

In Vivo

Nociceptin (1-7) (intrathecal injection; 150–1200 nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1–7) is injected simultaneously with nociceptin (3.0 fmol), nociceptin-induced hyperalgesia is significantly reduced^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice^[1]
Dosage:

150–1200 nmol
Administration:

Intrathecal injection; single dose
Result:

Co-treatment with nociceptin could reduce hyperalgesia.

Chemical Information

CAS No. 178249-42-8
Molecular Weight 655.70
Formula C₃₁H₄₁N₇O₉
Sequence

Phe-Gly-Gly-Phe-Thr-Gly-Ala
Sequence Shortening

FGGFTGA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. T Sakurada, et al. Nociceptin (1 - 7) antagonizes nociceptin-induced hyperalgesia in mice.Br J Pharmacol. 1999 Nov;128(5):941-4. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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Nociceptin(1-7)

All Opioid Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Nociceptin(1-7) Related Classifications

HY-P1319 Related Classifications