2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Nociceptin(1-7)

Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo.

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Nociceptin(1-7) Chemical Structure

Nociceptin(1-7) Chemical Structure

CAS No. : 178249-42-8

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Nociceptin(1-7) Related Antibodies

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Description

Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo[1].

In Vivo

Nociceptin (1-7) (intrathecal injection; 150–1200  nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1–7) is injected simultaneously with nociceptin (3.0 fmol), nociceptin-induced hyperalgesia is significantly reduced[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 150–1200  nmol
Administration: Intrathecal injection; single dose
Result: Co-treatment with nociceptin could reduce hyperalgesia.
Molecular Weight

655.70

Formula

C31H41N7O9
CAS No.
Sequence

Phe-Gly-Gly-Phe-Thr-Gly-Ala
Sequence Shortening

FGGFTGA
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nociceptin(1-7) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nociceptin(1-7)178249-42-8Opioid ReceptorNociceptivethermal threshold,?hyperalgesiaspinal cordorphan opioid-like receptorAnalgesiahyperalgesiametaboliteN-terminalfragmentInhibitorinhibitorinhibit

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