1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Nociceptin(1-7)

Nociceptin(1-7) 

Cat. No.: HY-P1319
Handling Instructions

Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo.

For research use only. We do not sell to patients.

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Nociceptin(1-7) Chemical Structure

Nociceptin(1-7) Chemical Structure

CAS No. : 178249-42-8

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Description

Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo[1].

In Vivo

Nociceptin (1-7) (intrathecal injection; 150–1200  nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1–7) is injected simultaneously with nociceptin (3.0 fmol), nociceptin-induced hyperalgesia is significantly reduced[1].

Animal Model: Mice[1]
Dosage: 150–1200  nmol
Administration: Intrathecal injection; single dose
Result: Co-treatment with nociceptin could reduce hyperalgesia.
Molecular Weight

655.70

Formula

C₃₁H₄₁N₇O₉

CAS No.

178249-42-8

Sequence Shortening

FGGFTGA

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Nociceptin(1-7)Opioid ReceptorNociceptivethermal threshold,?hyperalgesiaspinal cordorphan opioid-like receptorAnalgesiahyperalgesiametaboliteN-terminalfragmentInhibitorinhibitorinhibit

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Nociceptin(1-7)
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HY-P1319
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