Guanidinosuccinic acid
Based on 1 publication(s) in Google Scholar
Guanidinosuccinic acid is a nitrogenous metabolite.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 6133-30-8
- Formula: C5H9N3O4
- Molecular Weight:175.14
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Guanidinosuccinic acid
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
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Human Endogenous Metabolite |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6133-30-8
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Appearance Solid
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Molecular Weight 175.14
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Formula C5H9N3O4
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Color White to off-white
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SMILES
O=C(O)C[C@@H](C(O)=O)NC(N)=N
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227
Solvent & Solubility
DMSO : 75 mg/mL (428.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 6 mg/mL (34.26 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 9.09 mg/mL (51.90 mM); Clear solution; Need ultrasonic
Protocol
Mice[2]
Randomly bred Swiss mice (male and female, body weight 13-25 g for the first series of experiments) are housed under standard environmentally controlled conditions. For another series of experiments, young Swiss mice 7, 14 and 21 days old are used. Injections of Guanidinosuccinic acid suspensions are delivered in volumes of 0.1 mL per 10 g body weight, i.p. and in doses between 250 and 1000 mg/kg (5 mice per dose, in duplicate). After injection, the mice are put in individual cylindrical transparent cages and observed for 1 h (for 2 h in the case of the young mice). Both CD50 and LD50 are calculated by probit analysis or moving average interpolation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Milstien S, et al. Role of intestinal microflora in the metabolism of guanidinosuccinic acid. J Bacteriol. 1973 May;114(2):641-4. [Content Brief]
[2]. D'Hooge R, et al. Behavioral toxicity of guanidinosuccinic acid in adult and young mice. Toxicol Lett. 1992 Dec;64-65 Spec No:773-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 5.7097 mL | 28.5486 mL | 57.0972 mL | 142.7429 mL |
| 5 mM | 1.1419 mL | 5.7097 mL | 11.4194 mL | 28.5486 mL | |
| 10 mM | 0.5710 mL | 2.8549 mL | 5.7097 mL | 14.2743 mL | |
| 15 mM | 0.3806 mL | 1.9032 mL | 3.8065 mL | 9.5162 mL | |
| 20 mM | 0.2855 mL | 1.4274 mL | 2.8549 mL | 7.1371 mL | |
| 25 mM | 0.2284 mL | 1.1419 mL | 2.2839 mL | 5.7097 mL | |
| 30 mM | 0.1903 mL | 0.9516 mL | 1.9032 mL | 4.7581 mL | |
| DMSO | 40 mM | 0.1427 mL | 0.7137 mL | 1.4274 mL | 3.5686 mL |
| 50 mM | 0.1142 mL | 0.5710 mL | 1.1419 mL | 2.8549 mL | |
| 60 mM | 0.0952 mL | 0.4758 mL | 0.9516 mL | 2.3790 mL | |
| 80 mM | 0.0714 mL | 0.3569 mL | 0.7137 mL | 1.7843 mL | |
| 100 mM | 0.0571 mL | 0.2855 mL | 0.5710 mL | 1.4274 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Guanidinosuccinic acid Related Classifications
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