1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Lapaquistat

Lapaquistat (Synonyms: T-91485)

Cat. No.: HY-14925 Purity: 99.79%
Handling Instructions

Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of TAK-475. Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy.

For research use only. We do not sell to patients.

Lapaquistat Chemical Structure

Lapaquistat Chemical Structure

CAS No. : 189059-71-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1088 In-stock
Estimated Time of Arrival: December 31
1 mg USD 280 In-stock
Estimated Time of Arrival: December 31
5 mg USD 820 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1400 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2800 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of TAK-475. Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy[1].

IC50 & Target

Cholesterol biosynthesis[1]

Molecular Weight

603.10

Formula

C₃₁H₃₉ClN₂O₈

CAS No.

189059-71-0

SMILES

O=C(O)CC1CCN(C(C[[email protected]@H]2C(N(CC(C)(C)CO)C3=CC=C(Cl)C=C3[[email protected]@H](C4=CC=CC(OC)=C4OC)O2)=O)=O)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (41.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6581 mL 8.2905 mL 16.5810 mL
5 mM 0.3316 mL 1.6581 mL 3.3162 mL
10 mM 0.1658 mL 0.8290 mL 1.6581 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (1.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (1.38 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (1.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

LapaquistatT-91485T91485T 91485Endogenous MetaboliteInhibitorinhibitorinhibit

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Product name:
Lapaquistat
Cat. No.:
HY-14925
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