1. Metabolic Enzyme/Protease
  2. Farnesyl Transferase
  3. Lapaquistat acetate

Lapaquistat acetate (Synonyms: TAK-475)

Cat. No.: HY-16274 Purity: >99.0%
Handling Instructions

Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene. Lapaquistat acetate (TAK-475) is originally intended use to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage.

For research use only. We do not sell to patients.

Lapaquistat acetate Chemical Structure

Lapaquistat acetate Chemical Structure

CAS No. : 189060-13-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 682 In-stock
Estimated Time of Arrival: December 31
1 mg USD 160 In-stock
Estimated Time of Arrival: December 31
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene[1]. Lapaquistat acetate (TAK-475) is originally intended use to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage[2].

IC50 & Target

Squalene synthase[1]

Molecular Weight

645.14

Formula

C₃₃H₄₁ClN₂O₉

CAS No.

189060-13-7

SMILES

O=C(O)CC1CCN(C(C[[email protected]@H]2C(N(CC(C)(C)COC(C)=O)C3=CC=C(Cl)C=C3[[email protected]@H](C4=CC=CC(OC)=C4OC)O2)=O)=O)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 46 mg/mL (71.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5501 mL 7.7503 mL 15.5005 mL
5 mM 0.3100 mL 1.5501 mL 3.1001 mL
10 mM 0.1550 mL 0.7750 mL 1.5501 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

LapaquistatTAK-475TAK475TAK 475Farnesyl TransferaseFtaseInhibitorinhibitorinhibit

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Product Name:
Lapaquistat acetate
Cat. No.:
HY-16274
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