1. Metabolic Enzyme/Protease
  2. Farnesyl Transferase
  3. Lapaquistat acetate

Lapaquistat acetate (Synonyms: TAK-475)

Cat. No.: HY-16274
Handling Instructions

Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene. Lapaquistat acetate (TAK-475) is originally intended use to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage.

For research use only. We do not sell to patients.

Lapaquistat acetate Chemical Structure

Lapaquistat acetate Chemical Structure

CAS No. : 189060-13-7

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Description

Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene[1]. Lapaquistat acetate (TAK-475) is originally intended use to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage[2].

IC50 & Target

Squalene synthase[1]

Molecular Weight

645.14

Formula

C₃₃H₄₁ClN₂O₉

CAS No.

189060-13-7

SMILES

O=C(O)CC1CCN(C(C[[email protected]@H]2C(N(CC(C)(C)COC(C)=O)C3=CC=C(Cl)C=C3[[email protected]@H](C4=CC=CC(OC)=C4OC)O2)=O)=O)CC1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Lapaquistat acetate
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HY-16274
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