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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
Abemaciclib
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "Abemaciclib" in MCE Product Catalog:
125
Target:
Research Areas:
Abemaciclib (LY2835219) is a selective and BBB-permeable CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively.
125
125 Publications Verification
Cat. No.: HY-16297
CAS No.: 1231930-82-7
Synonyms: LY2835219 methanesulfonate
Abemaciclib methanesulfonate (LY2835219 methanesulfonate) is a selective and BBB-permeable CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4 and CDK6, respectively .
6
Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor for the treatment of cancer .
3
3 Cited Publications
Synonyms: LSN3106729 hydrochloride
Research Areas:
Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader .
3
Target:
Research Areas:
Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity .
3
Research Areas:
Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader .
Cat. No.: HY-16297AR
CAS No.: 1231929-97-7
Synonyms: LY2835219 (Standard)
Target:
Research Areas:
Abemaciclib (Standard) is the analytical standard of Abemaciclib. This product is intended for research and analytical applications. Abemaciclib (LY2835219) is a selective and BBB-permeable CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively.
Cat. No.: HY-16297AS
CAS No.: 2088650-53-5
Synonyms: LY2835219-d8
Cat. No.: HY-129336S
Purity: 97.01%
Synonyms: LSN3106726-d8
Cat. No.: HY-128669S
Purity: 99.25%
Synonyms: LSN2839567-d6
Cat. No.: HY-78066
CAS No.: 1231930-33-8
Synonyms: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Target:
Research Areas:
Abemaciclib Impurity 1 (6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole) is a drug intermediate for synthesis of various active compounds.
Cat. No.: HY-168996
CAS No.: 3032908-44-1
LA-CB1 is an Abemaciclib (HY-16297A) derivative that targets CDK4/6 and promotes its degradation via the ubiquitin-proteasome pathway, thereby disrupting the CDK4/6-Cyclin D1-Rb-E2F axis and inducing G0/G1 cell cycle arrest and apoptosis. LA-CB1 exhibits antiproliferative activity against MDA-MB-231 cells, with an IC50 of 0.27 µM, and effectively inhibits epithelial-mesenchymal transition (EMT), cell migration, invasion, and angiogenesis. In highly aggressive models such as triple-negative breast cancer (TNBC), LA-CB1 significantly suppresses tumor growth in a dose-dependent manner. LA-CB1 holds potential for research in the field of breast cancer .
Cat. No.: HY-16297R
CAS No.: 1231930-82-7
Synonyms: LY2835219 methanesulfonate (Standard)
Target:
Research Areas:
Abemaciclib (methanesulfonate) (Standard) is the analytical standard of Abemaciclib (methanesulfonate). This product is intended for research and analytical applications. Abemaciclib methanesulfonate (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4 and CDK6, respectively .
Cat. No.: HY-126534S
Purity: 98.47%
Synonyms: LSN3106729-d8
Cat. No.: HY-W728130
CAS No.: 1809251-51-1
Synonyms: LY2835219-d5
Cat. No.: HY-128669R
CAS No.: 1231930-57-6
Synonyms: LSN2839567 (Standard)
Target:
Research Areas:
Abemaciclib metabolite M2 (Standard) is the analytical standard of Abemaciclib metabolite M2. This product is intended for research and analytical applications. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity[1][2].
Cat. No.: HY-78066S
Synonyms: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole-d12
Cat. No.: HY-78066S1
CAS No.: 2088650-87-5
Synonyms: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole-d5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
