1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. Tofacitinib metabolite-1

Tofacitinib metabolite-1 

Cat. No.: HY-136336 Purity: 99.59%
Handling Instructions

Tofacitinib metabolite-1 is a metabolite of Tofacitinib, a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib.

For research use only. We do not sell to patients.

Tofacitinib metabolite-1 Chemical Structure

Tofacitinib metabolite-1 Chemical Structure

CAS No. : 1640971-51-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 528 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 528 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Tofacitinib metabolite-1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tofacitinib metabolite-1 is a metabolite of Tofacitinib, a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib[1][2].

Molecular Weight

328.37

Formula

C16H20N6O2

CAS No.
SMILES

CN([[email protected]]([[email protected]@H](CC1)C)CN1C(CC#N)=O)C2=C(CC3=O)C(N3)=NC=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (304.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0453 mL 15.2267 mL 30.4535 mL
5 mM 0.6091 mL 3.0453 mL 6.0907 mL
10 mM 0.3045 mL 1.5227 mL 3.0453 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.5 mg/mL (7.61 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.59%

References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Tofacitinib metabolite-1
Cat. No.:
HY-136336
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