2. Dihydrocurcumin

Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways.

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Dihydrocurcumin Chemical Structure

Dihydrocurcumin Chemical Structure

CAS No. : 76474-56-1

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Dihydrocurcumin Related Antibodies

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Description

Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways[1].

In Vitro

Dihydrocurcumin (0-50 μM, 24 h) decreases OA induced TG level in HepG2 and L02 cells[1].
Dihydrocurcumin (0-50 μM, 24 h) promotes glucose uptake and reduces the levels of cellular NO and ROS[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dihydrocurcumin Related Antibodies
Molecular Weight

370.40

Formula

C21H22O6
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(/C=C(O)/C=C/C1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (67.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6998 mL 13.4989 mL 26.9978 mL
5 mM 0.5400 mL 2.6998 mL 5.3996 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.77%

COA (243 KB) HNMR (129 KB) RP-HPLC (139 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6998 mL 13.4989 mL 26.9978 mL 67.4946 mL
5 mM 0.5400 mL 2.6998 mL 5.3996 mL 13.4989 mL
10 mM 0.2700 mL 1.3499 mL 2.6998 mL 6.7495 mL
15 mM 0.1800 mL 0.8999 mL 1.7999 mL 4.4996 mL
20 mM 0.1350 mL 0.6749 mL 1.3499 mL 3.3747 mL
25 mM 0.1080 mL 0.5400 mL 1.0799 mL 2.6998 mL
30 mM 0.0900 mL 0.4500 mL 0.8999 mL 2.2498 mL
40 mM 0.0675 mL 0.3375 mL 0.6749 mL 1.6874 mL
50 mM 0.0540 mL 0.2700 mL 0.5400 mL 1.3499 mL
60 mM 0.0450 mL 0.2250 mL 0.4500 mL 1.1249 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihydrocurcumin76474-56-1Inhibitorinhibitorinhibit

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