D-Glucose 6-phosphate sodium
Based on 3 publication(s) in Google Scholar
D-Glucose 6-phosphate sodium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate sodium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate sodium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 54010-71-8
- Formula: C6H12NaO9P
- Molecular Weight:282.12
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Triphenyl phosphate -
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D-Glucose 6-phosphate disodium salt -
HY-128374R
D-Glucose 6-phosphate disodium salt (Standard) -
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Tri-O-tolyl phosphate -
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Antimalarial agent 1
Publications Citing Use of MedChemExpress (MCE) D-Glucose 6-phosphate sodium
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
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Human Endogenous Metabolite |
In Vitro
D‑Glucose 6‑phosphate sodium is central to the mechanism by which insulin activates glycogen synthesis. It not only allosterically activates glycogen synthase but, more importantly, promotes its dephosphorylation to achieve covalent and sustained activation, thereby driving glycogen synthesis[1].
D‑Glucose 6‑phosphate sodium accumulates following the inhibition of phosphoglucose isomerase activity, which in turn activates the mTOR pathway and promotes protein synthesis in cardiomyocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 54010-71-8
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Appearance Solid
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Molecular Weight 282.12
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Formula C6H12NaO9P
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Color White to off-white
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SMILES
O=C[C@@H]([C@H]([C@@H]([C@@H](COP(O)(O)=O)O)O)O)[O-].[Na+]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Commun
Structural basis for transport and inhibition of the human glucose-6-phosphate transporter G6PT. [Abstract]2025 Oct 24;16(1):9420. PMID: 41136424 -
Insect Biochem Mol Biol
Development of an efficient insecticide substrate and inhibitor screening system of insect P450s using fission yeast. [Abstract]2023 Jun:157:103958. PMID: 37182814 -
Microb Pathog
Sub-minimum inhibitory concentrations of fosfomycin enhance Staphylococcus aureus virulence through the agr-PSM pathway. [Abstract]2026 Jan:210:108138. PMID: 41429753
Solvent & Solubility
In Vitro:
H2O : 50 mg/mL (177.23 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Villar-Palasí C, et al. The role of glucose 6-phosphate in the control of glycogen synthase. FASEB J. 1997;11(7):544-558. [Content Brief]
[2]. Karlstaedt A, et al. Glucose 6-Phosphate Accumulates via Phosphoglucose Isomerase Inhibition in Heart Muscle. Circ Res. 2020;126(1):60-74. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.5446 mL | 17.7230 mL | 35.4459 mL | 88.6148 mL |
| 5 mM | 0.7089 mL | 3.5446 mL | 7.0892 mL | 17.7230 mL | |
| 10 mM | 0.3545 mL | 1.7723 mL | 3.5446 mL | 8.8615 mL | |
| 15 mM | 0.2363 mL | 1.1815 mL | 2.3631 mL | 5.9077 mL | |
| 20 mM | 0.1772 mL | 0.8861 mL | 1.7723 mL | 4.4307 mL | |
| 25 mM | 0.1418 mL | 0.7089 mL | 1.4178 mL | 3.5446 mL | |
| 30 mM | 0.1182 mL | 0.5908 mL | 1.1815 mL | 2.9538 mL | |
| 40 mM | 0.0886 mL | 0.4431 mL | 0.8861 mL | 2.2154 mL | |
| 50 mM | 0.0709 mL | 0.3545 mL | 0.7089 mL | 1.7723 mL | |
| 60 mM | 0.0591 mL | 0.2954 mL | 0.5908 mL | 1.4769 mL | |
| 80 mM | 0.0443 mL | 0.2215 mL | 0.4431 mL | 1.1077 mL | |
| 100 mM | 0.0354 mL | 0.1772 mL | 0.3545 mL | 0.8861 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Glucose 6-phosphate sodium Related Classifications
HY-112537B Related Classifications
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