54010-71-8
Chemical Structure
D-Glucose 6-phosphate sodium
- CAS No.: 54010-71-8
- Formula:C6H12NaO9P
- Molecular Weight:282.12
IUPAC Name: sodium (2R,3R,4R,5R)-3,4,5-trihydroxy-1-oxo-6-(phosphonooxy)hexan-2-olate
InChIKey: WMDZTFJMKZDWKW-BTVCFUMJSA-N
SMILES: O=C[C@@H]([C@H]([C@@H]([C@@H](COP(O)(O)=O)O)O)O)[O-].[Na+]
Biological Activity: D-Glucose 6-phosphate sodium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate sodium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate sodium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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D-Glucose 6-phosphate sodium | 98.0% | D-Glucose 6-phosphate sodium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate sodium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate sodium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure. | ||||||||||||||||||||
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References
- [1]. Villar-Palasí C, et al. The role of glucose 6-phosphate in the control of glycogen synthase. FASEB J. 1997;11(7):544-558. [Content Brief]
- [2]. Karlstaedt A, et al. Glucose 6-Phosphate Accumulates via Phosphoglucose Isomerase Inhibition in Heart Muscle. Circ Res. 2020;126(1):60-74. [Content Brief]
