D-Glucose 6-phosphate
Based on 4 publication(s) in Google Scholar
D-Glucose 6-phosphate is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate can be used in research related to non-insulin-dependent diabetes mellitus and heart failure.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 56-73-5
- Formula: C6H13O9P
- Molecular Weight:260.14
-
Storage:
Solution, -20°C, 2 years
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) D-Glucose 6-phosphate
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
|
Human Endogenous Metabolite |
D‑Glucose 6‑phosphate is central to the mechanism by which insulin activates glycogen synthesis. It not only allosterically activates glycogen synthase but, more importantly, promotes its dephosphorylation to achieve covalent and sustained activation, thereby driving glycogen synthesis[1].
D‑Glucose 6‑phosphate accumulates following the inhibition of phosphoglucose isomerase activity, which in turn activates the mTOR pathway and promotes protein synthesis in cardiomyocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 56-73-5
-
Appearance Liquid
-
Molecular Weight 260.14
-
Formula C6H13O9P
-
Color Colorless to light yellow
-
SMILES
O=C[C@@H]([C@H]([C@@H]([C@@H](COP(O)(O)=O)O)O)O)O
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Solution, -20°C, 2 years
Publications (4)
-
Journal Impact Factor
-
Most Recent
-
Cell Stem Cell
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis. [Abstract]2022 Jul 7;29(7):1119-1134.e7. PMID: 35803229 -
Nat Commun
Structural basis for transport and inhibition of the human glucose-6-phosphate transporter G6PT. [Abstract]2025 Oct 24;16(1):9420. PMID: 41136424 -
Insect Biochem Mol Biol
Development of an efficient insecticide substrate and inhibitor screening system of insect P450s using fission yeast. [Abstract]2023 Jun:157:103958. PMID: 37182814 -
Microb Pathog
Sub-minimum inhibitory concentrations of fosfomycin enhance Staphylococcus aureus virulence through the agr-PSM pathway. [Abstract]2026 Jan:210:108138. PMID: 41429753
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (477 KB)
- English - EN (477 KB)
- Français - FR (477 KB)
- Deutsch - DE (477 KB)
- Norwegian - NO (477 KB)
- Español - ES (477 KB)
- Swedish - SV (477 KB)
- Italian - IT (477 KB)
- Korean - KR (477 KB)
- Portuguese - PT (477 KB)
-
Handling Instructions (2659 KB)
References
[1]. Villar-Palasí C, et al. The role of glucose 6-phosphate in the control of glycogen synthase. FASEB J. 1997;11(7):544-558. [Content Brief]
[2]. Karlstaedt A, et al. Glucose 6-Phosphate Accumulates via Phosphoglucose Isomerase Inhibition in Heart Muscle. Circ Res. 2020;126(1):60-74. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz