D-Glucose 6-phosphate dipotassium
Based on 3 publication(s) in Google Scholar
D-Glucose 6-phosphate dipotassium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate dipotassium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate dipotassium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure.
For research use only. We do not sell to patients.
- CAS No.: 5996-17-8
- Formula: C6H11K2O9P
- Molecular Weight:336.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) D-Glucose 6-phosphate dipotassium
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
D‑Glucose 6‑phosphate dipotassium is central to the mechanism by which insulin activates glycogen synthesis. It not only allosterically activates glycogen synthase but, more importantly, promotes its dephosphorylation to achieve covalent and sustained activation, thereby driving glycogen synthesis[1].
D‑Glucose 6‑phosphate dipotassium accumulates following the inhibition of phosphoglucose isomerase activity, which in turn activates the mTOR pathway and promotes protein synthesis in cardiomyocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5996-17-8
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Molecular Weight 336.32
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Formula C6H11K2O9P
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SMILES
O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O[K])(O[K])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Commun
Structural basis for transport and inhibition of the human glucose-6-phosphate transporter G6PT. [Abstract]2025 Oct 24;16(1):9420. PMID: 41136424 -
Insect Biochem Mol Biol
Development of an efficient insecticide substrate and inhibitor screening system of insect P450s using fission yeast. [Abstract]2023 Jun:157:103958. PMID: 37182814 -
Microb Pathog
Sub-minimum inhibitory concentrations of fosfomycin enhance Staphylococcus aureus virulence through the agr-PSM pathway. [Abstract]2026 Jan:210:108138. PMID: 41429753
Purity & Documentation
References
[1]. Villar-Palasí C, et al. The role of glucose 6-phosphate in the control of glycogen synthase. FASEB J. 1997;11(7):544-558. [Content Brief]
[2]. Karlstaedt A, et al. Glucose 6-Phosphate Accumulates via Phosphoglucose Isomerase Inhibition in Heart Muscle. Circ Res. 2020;126(1):60-74. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
D-Glucose 6-phosphate dipotassium Related Classifications
HY-112537A Related Classifications
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