5996-17-8
Chemical Structure
D-Glucose 6-phosphate dipotassium
- CAS No.: 5996-17-8
- Formula:C6H11K2O9P
- Molecular Weight:336.32
IUPAC Name: potassium (2R,3R,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexyl phosphate
InChIKey: BWHWCIODKVRLNE-FAOVPRGRSA-L
SMILES: O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O[K])(O[K])=O
Biological Activity: D-Glucose 6-phosphate dipotassium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate dipotassium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate dipotassium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure[1][2].
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D-Glucose 6-phosphate dipotassium | D-Glucose 6-phosphate dipotassium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate dipotassium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate dipotassium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure. | |||||||||||||||||||||
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- [1]. Villar-Palasí C, et al. The role of glucose 6-phosphate in the control of glycogen synthase. FASEB J. 1997;11(7):544-558. [Content Brief]
- [2]. Karlstaedt A, et al. Glucose 6-Phosphate Accumulates via Phosphoglucose Isomerase Inhibition in Heart Muscle. Circ Res. 2020;126(1):60-74. [Content Brief]
Keywords
