3-Phosphoglyceric acid

Cat. No.: HY-113491: FAQs
Data Sheet Handling Instructions

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3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid is involved in alveolar macrophage epigenetic regulation.

For research use only. We do not sell to patients.

3-Phosphoglyceric acid Chemical Structure

CAS No. : 820-11-1

Size	Price	Stock
5 mg	USD 370	Ask For Quote & Lead Time
10 mg	USD 600	Ask For Quote & Lead Time
25 mg	USD 1200	Ask For Quote & Lead Time
50 mg	USD 1920	Ask For Quote & Lead Time

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Biological Activity
Purity & Documentation
References
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Description

3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid is involved in alveolar macrophage epigenetic regulation.

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

3-Phosphoglyceric acid (400 µM; 24 hours; BMDMs) treatment enhances Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification is also reversed^[1].
3-Phosphoglyceric treatment significantly augmentes gene expression as well as H3K4me3 deposition of Spp1 in IL-4-stimulated macrophages^[1].
In yeast, 3-Phosphoglyceric acid acts as a metabolic checkpoint for the formation of a multicomponent enzyme complex including serine metabolic enzymes and pyruvate kinase isoform 2 (PKM2) homologue, which senses both serine metabolism and glycolysis and regulates H3K4 methylation and histone phosphorylation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:	Bone marrow-derived macrophages (BMDMs)
Concentration:	400 µM
Incubation Time:	24 hours
Result:	Enhanced Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification was also reversed.

Molecular Weight

186.06

Formula

C₃H₇O₇P

CAS No.

820-11-1

SMILES

O=C(O)C(O)COP(O)(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (537.46 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.3746 mL	26.8731 mL	53.7461 mL
5 mM	1.0749 mL	5.3746 mL	10.7492 mL
10 mM	0.5375 mL	2.6873 mL	5.3746 mL

View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang W, et al. The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. J Exp Med. 2018 Dec 3;215(12):3180-3193. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.3746 mL	26.8731 mL	53.7461 mL	134.3653 mL
	5 mM	1.0749 mL	5.3746 mL	10.7492 mL	26.8731 mL
	10 mM	0.5375 mL	2.6873 mL	5.3746 mL	13.4365 mL
	15 mM	0.3583 mL	1.7915 mL	3.5831 mL	8.9577 mL
	20 mM	0.2687 mL	1.3437 mL	2.6873 mL	6.7183 mL
	25 mM	0.2150 mL	1.0749 mL	2.1498 mL	5.3746 mL
	30 mM	0.1792 mL	0.8958 mL	1.7915 mL	4.4788 mL
	40 mM	0.1344 mL	0.6718 mL	1.3437 mL	3.3591 mL
	50 mM	0.1075 mL	0.5375 mL	1.0749 mL	2.6873 mL
	60 mM	0.0896 mL	0.4479 mL	0.8958 mL	2.2394 mL
	80 mM	0.0672 mL	0.3359 mL	0.6718 mL	1.6796 mL
	100 mM	0.0537 mL	0.2687 mL	0.5375 mL	1.3437 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.