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  3. 3-Phosphoglyceric acid

3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid is involved in alveolar macrophage epigenetic regulation.

For research use only. We do not sell to patients.

3-Phosphoglyceric acid Chemical Structure

3-Phosphoglyceric acid Chemical Structure

CAS No. : 820-11-1

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10 mg USD 600 In-stock
25 mg USD 1200 In-stock
50 mg USD 1920 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid is involved in alveolar macrophage epigenetic regulation.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

3-Phosphoglyceric acid (400 µM; 24 hours; BMDMs) treatment enhances Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification is also reversed[1].
3-Phosphoglyceric treatment significantly augmentes gene expression as well as H3K4me3 deposition of Spp1 in IL-4-stimulated macrophages[1].
In yeast, 3-Phosphoglyceric acid acts as a metabolic checkpoint for the formation of a multicomponent enzyme complex including serine metabolic enzymes and pyruvate kinase isoform 2 (PKM2) homologue, which senses both serine metabolism and glycolysis and regulates H3K4 methylation and histone phosphorylation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Bone marrow-derived macrophages (BMDMs)
Concentration: 400 µM
Incubation Time: 24 hours
Result: Enhanced Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification was also reversed.
Molecular Weight

186.06

Formula

C3H7O7P

CAS No.
Appearance

Solid

Color

Pale purple to light pink

SMILES

O=C(O)C(O)COP(O)(O)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (537.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3746 mL 26.8731 mL 53.7461 mL
5 mM 1.0749 mL 5.3746 mL 10.7492 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.3746 mL 26.8731 mL 53.7461 mL 134.3653 mL
5 mM 1.0749 mL 5.3746 mL 10.7492 mL 26.8731 mL
10 mM 0.5375 mL 2.6873 mL 5.3746 mL 13.4365 mL
15 mM 0.3583 mL 1.7915 mL 3.5831 mL 8.9577 mL
20 mM 0.2687 mL 1.3437 mL 2.6873 mL 6.7183 mL
25 mM 0.2150 mL 1.0749 mL 2.1498 mL 5.3746 mL
30 mM 0.1792 mL 0.8958 mL 1.7915 mL 4.4788 mL
40 mM 0.1344 mL 0.6718 mL 1.3437 mL 3.3591 mL
50 mM 0.1075 mL 0.5375 mL 1.0749 mL 2.6873 mL
60 mM 0.0896 mL 0.4479 mL 0.8958 mL 2.2394 mL
80 mM 0.0672 mL 0.3359 mL 0.6718 mL 1.6796 mL
100 mM 0.0537 mL 0.2687 mL 0.5375 mL 1.3437 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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3-Phosphoglyceric acid
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HY-113491
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