Mannose 6 phosphate 

Mannose 6 phosphate is an essential precursor for mannosyl glycoconjugates, including lipid-linked oligosaccharides (LLO; glucose3mannose9GlcNAc2-P-P-dolichol) used for protein N-glycosylation. Mannose 6 phosphate causes specific LLO cleavage. Mannose 6 phosphate causes specific degradation of G3M9Gn2-P-P-Dol. Complexes containing Mannose 6 phosphate can remodel the dermal collagen network, improve skin biomechanical properties, and reverse visible signs of aging. Mannose 6 phosphate can be used in research related to skin aging^[1][2].

Complexes containing Mannose 6-phosphate can reorganize the dermal collagen network, improve skin biomechanical properties, and reverse visible signs of skin aging^[1].
Mannose 6 phosphate causes specific LLO cleavage in permeabilized mammalian cells^[2].
Mannose 6 phosphate (50 µM) causes specific degradation of G3M9Gn2-P-P-Dol in a variety of Streptolysin-O (HY-135416)-permeabilized mammalian cells (dermal fibroblasts, CHO-K1 cells, and primary hepatocytes), and release of free G3M9Gn2^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

260.14

C₆H₁₃O₉P

3672-15-9

O=C[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gao N, et al. Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides. Mol Biol Cell. 2011 Sep;22(17):2994-3009.  [Content Brief]

  [2]. Meunier M, et al. Mannose-6-phosphate complex and improvement in biomechanical properties of the skin. J Cosmet Dermatol. 2021;20(6):1598-1610.  [Content Brief]