Mannose 6 phosphate
Mannose 6 phosphate is an essential precursor for mannosyl glycoconjugates, including lipid-linked oligosaccharides (LLO; glucose3mannose9GlcNAc2-P-P-dolichol) used for protein N-glycosylation. Mannose 6 phosphate causes specific LLO cleavage. Mannose 6 phosphate causes specific degradation of G3M9Gn2-P-P-Dol. Complexes containing Mannose 6 phosphate can remodel the dermal collagen network, improve skin biomechanical properties, and reverse visible signs of aging. Mannose 6 phosphate can be used in research related to skin aging.
For research use only. We do not sell to patients.
- CAS No.: 3672-15-9
- Formula: C6H13O9P
- Molecular Weight:260.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Complexes containing Mannose 6-phosphate can reorganize the dermal collagen network, improve skin biomechanical properties, and reverse visible signs of skin aging[1].
Mannose 6 phosphate causes specific LLO cleavage in permeabilized mammalian cells[2].
Mannose 6 phosphate (50 µM) causes specific degradation of G3M9Gn2-P-P-Dol in a variety of Streptolysin-O (HY-135416)-permeabilized mammalian cells (dermal fibroblasts, CHO-K1 cells, and primary hepatocytes), and release of free G3M9Gn2[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3672-15-9
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Molecular Weight 260.14
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Formula C6H13O9P
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SMILES
O=C[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Gao N, et al. Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides. Mol Biol Cell. 2011 Sep;22(17):2994-3009. [Content Brief]
[2]. Meunier M, et al. Mannose-6-phosphate complex and improvement in biomechanical properties of the skin. J Cosmet Dermatol. 2021;20(6):1598-1610. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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