1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Streptolysin O

Streptolysin O 

Cat. No.: HY-135416
Handling Instructions

Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .

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Streptolysin O Chemical Structure

Streptolysin O Chemical Structure

CAS No. : 98072-47-0

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Description

Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state [1][2][3][4].

In Vitro

When Streptolysin O is secreted by streptococci, it is in an active state, but it rapidly oxidizes to a reversibly inactive state with the formation of disulfide bonds[2].
Streptolysin O, belongs to the group of thiol-activated toxins, is a secreted virulence factor of GAS that induces apoptosis in neutrophils and macrophages at later time points (~4 h). Streptolysin O induces eukaryotic cell lysis in a cholesterol-dependent manner, is highly upregulated in the GAS M1T1 clone during bloodstream dissemination. Streptolysin O is known to promote Group A Streptococcus (GAS) resistance to phagocytic clearance by neutrophils, a critical first element of host defense against invasive bacterial infection[3].

Clinical Trial
CAS No.

98072-47-0

SMILES

[Hemolysins O, Streptococcus group A]

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Streptolysin OEndogenous Metaboliteoxygen-labilestreptococcalhemolysinprototypecholesterol-bindingbacterialexotoxinpermeabilizationvirulenceInhibitorinhibitorinhibit

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