98072-47-0
98072-47-0
Chemical Structure
Biological Activity: Streptolysin O is a cholesterol-targeting, thiol-activated pore-forming toxin. Streptolysin O binds to cholesterol via its C-terminal domain 4, oligomerizes to form arc-shaped or ring-shaped structures, inserts amphipathic helices into the lipid bilayer, and forms transmembrane β-barrel pores, resulting in cell permeabilization. Streptolysin O enables controllable cell membrane permeabilization, fluorescent probe delivery, and exogenous molecule uptake[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Streptolysin O | Streptolysin O is a cholesterol-targeting, thiol-activated pore-forming toxin. Streptolysin O binds to cholesterol via its C-terminal domain 4, oligomerizes to form arc-shaped or ring-shaped structures, inserts amphipathic helices into the lipid bilayer, and forms transmembrane β-barrel pores, resulting in cell permeabilization. Streptolysin O enables controllable cell membrane permeabilization, fluorescent probe delivery, and exogenous molecule uptake. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Recombinant Streptolysin O | Recombinant Streptolysin O is a cholesterol-targeting, thiol-activated pore-forming toxin. Recombinant Streptolysin O binds to cholesterol via its C-terminal domain 4, oligomerizes to form arc-shaped or ring-shaped structures, inserts amphipathic helices into the lipid bilayer, and forms transmembrane β-barrel pores, resulting in cell permeabilization. Recombinant Streptolysin O enables controllable cell membrane permeabilization, fluorescent probe delivery, and exogenous molecule uptake. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Vita GM, et al. Human Serum Albumin Binds Streptolysin O (SLO) Toxin Produced by Group A and Inhibits Its Cytotoxic and Hemolytic Effects. Frontiers in immunology. 2020;11:507092. [Content Brief]
- [2]. Palmer M, et al. Membrane-penetrating domain of streptolysin O identified by cysteine scanning mutagenesis. The Journal of biological chemistry. 1996 Oct 25;271(43):26664-7. [Content Brief]
- [3]. Teng KW, et al. Delivery of Fluorescent Probes Using Streptolysin O for Fluorescence Microscopy of Living Cells. Current protocols in protein science. 2018 Aug;93(1):e60. [Content Brief]
- [4]. Sim BW, et al. Efficient production of transgenic mice by intracytoplasmic injection of streptolysin-O-treated spermatozoa. Molecular reproduction and development. 2013 Mar;80(3):233-41. [Content Brief]
- [5]. Uchiyama S, et al. Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus. Frontiers in immunology. 2015;6:581. [Content Brief]
