NADP sodium salt
Based on 7 publication(s) in Google Scholar
NADP sodium salt is the sodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.04%
- CAS. Nr.: 1184-16-3
- Formel: C21H27N7NaO17P3
- Molecular Weight:765.39
-
Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
Immunology/Inflammation Compound Library
HY-L007
-
Metabolism/Protease Compound Library
HY-L012
-
Anti-Cancer Compound Library
HY-L025
-
Human Endogenous Metabolite Compound Library
HY-L030
-
Anti-Aging Compound Library
HY-L034
-
Nucleotide Compound Library
HY-L044
-
Oxygen Sensing Compound Library
HY-L045
-
Anti-Breast Cancer Compound Library
HY-L074
-
Food-Sourced Compound Library
HY-L094
-
Human Metabolite Library
HY-L123
-
Animal-Sourced Natural Product Library
HY-L157
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Vitamin Compound Library
HY-L197
-
High-Throughput Bioactive Compound Library
HY-L205
-
Mass Spectrometry Human Endogenous Metabolite Library
HY-L207
-
Mass Spectrometry Human Metabolite Library
HY-L215
Publications Citing Use of MedChemExpress (MCE) NADP sodium salt
More- J Adv Res. 2026 Apr 13:S2090-1232(26)00338-3. [Abstract]
- Cell Prolif. 2021 Apr;54(4):e13015. [Abstract]
- Cell Oncol (Dordr). 2023 Jun;46(3):761-776. [Abstract]
- Eur J Pharm Sci. 2023 Aug 1:187:106475. [Abstract]
- World J Microbiol Biotechnol. 2024 Oct 19;40(11):357. [Abstract]
- FASEB J. 2024 Jul 31;38(14):e23844. [Abstract]
- Insect Biochem Mol Biol. 2023 Jun:157:103958. [Abstract]
Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
|
Human Endogenous Metabolite |
NADP sodium salt can impair folate metabolism and nucleotide biosynthesis in HCT116 cells at high concentrations, leading to the cessation of proliferation and prioritizing cell survival[1]. NADP sodium salt forms NAADP through IL-8-driven CD38 to mobilize Ca2+ and influence cell migration[2]. NADP sodium salt de novo synthesis mediated by NADK upregulation provides power for anabolic reaction and antioxidant system to promote breast cancer metastasis[3]. NADP sodium salt is upregulated in ROS generation mediated by hyperglycemia and IDPc induction, thereby protecting renal cells from oxidative stress[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 1184-16-3
-
Appearance Solid
-
Molecular Weight 765.39
-
Formel C21H27N7NaO17P3
-
Color White to off-white
-
SMILES
O[C@H]1[C@@H](O)[C@H]([N+]2=CC=CC(C(N)=O)=C2)O[C@@H]1COP([O-])(OP(OC[C@@H]3[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](N(C4=NC=N5)C=NC4=C5N)O3)([O-])=O)=O.[Na+]
-
Synonyms
Sodium NADP
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
-
Journal Impact Factor
-
Most Recent
-
J Adv Res
A "DUBTAC" targeting GLUL deubiquitination promotes BMSC osteogenic differentiation and implant osseointegration in type 2 diabetes. [Abstract]2026 Apr 13:S2090-1232(26)00338-3. PMID: 41980623 -
Cell Prolif
TSP50 promotes hepatocyte proliferation and tumour formation by activating glucose-6-phosphate dehydrogenase (G6PD). [Abstract]2021 Apr;54(4):e13015. PMID: 33630390 -
Cell Oncol (Dordr)
LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation. [Abstract]2023 Jun;46(3):761-776. PMID: 36913068 -
Eur J Pharm Sci
Investigating the relevance of CYP2J2 inhibition for drugs known to cause intermediate to high risk torsades de pointes. [Abstract]2023 Aug 1:187:106475. PMID: 37225005 -
World J Microbiol Biotechnol
Molecular insights and functional analysis of isocitrate dehydrogenase in two gram-negative pathogenic bacteria. [Abstract]2024 Oct 19;40(11):357. PMID: 39425873 -
FASEB J
Desaminotyrosine is a redox-active microbial metabolite that bolsters macrophage antimicrobial functions while attenuating IL-6 production. [Abstract]2024 Jul 31;38(14):e23844. PMID: 39046365 -
Insect Biochem Mol Biol
Development of an efficient insecticide substrate and inhibitor screening system of insect P450s using fission yeast. [Abstract]2023 Jun:157:103958. PMID: 37182814
Lösungsmittel & Löslichkeit
H2O : 100 mg/mL (130.65 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (130.65 mM); Clear solution; Need ultrasonic
Reinheit & Dokumentation
-
Data Sheet (282 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Chen L, et al. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nat Metab. 2019 Mar;1:404-415. Epub 2019 Mar 11. PMID: 31058257; PMCID: PMC6489125. [Content Brief]
[2]. Nam TS, et al. Interleukin-8 drives CD38 to form NAADP from NADP+ and NAAD in the endolysosomes to mobilize Ca2+ and effect cell migration. FASEB J. 2020 Sep;34(9):12565-12576. [Content Brief]
[3]. Ilter D, et al. NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Redox Biol. 2023 May;61:102627. [Content Brief]
[4]. Lee SH, et al. Upregulation of cytosolic NADP+-dependent isocitrate dehydrogenase by hyperglycemia protects renal cells against oxidative stress. Mol Cells. 2010 Feb 28;29(2):203-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.3065 mL | 6.5326 mL | 13.0652 mL | 32.6631 mL |
| 5 mM | 0.2613 mL | 1.3065 mL | 2.6130 mL | 6.5326 mL | |
| 10 mM | 0.1307 mL | 0.6533 mL | 1.3065 mL | 3.2663 mL | |
| 15 mM | 0.0871 mL | 0.4355 mL | 0.8710 mL | 2.1775 mL | |
| 20 mM | 0.0653 mL | 0.3266 mL | 0.6533 mL | 1.6332 mL | |
| 25 mM | 0.0523 mL | 0.2613 mL | 0.5226 mL | 1.3065 mL | |
| 30 mM | 0.0436 mL | 0.2178 mL | 0.4355 mL | 1.0888 mL | |
| 40 mM | 0.0327 mL | 0.1633 mL | 0.3266 mL | 0.8166 mL | |
| 50 mM | 0.0261 mL | 0.1307 mL | 0.2613 mL | 0.6533 mL | |
| 60 mM | 0.0218 mL | 0.1089 mL | 0.2178 mL | 0.5444 mL | |
| 80 mM | 0.0163 mL | 0.0817 mL | 0.1633 mL | 0.4083 mL | |
| 100 mM | 0.0131 mL | 0.0653 mL | 0.1307 mL | 0.3266 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NADP sodium salt Related Classifications
HY-F0002 Related Classifications
Powered by Bioz