NADP disodium salt
Based on 7 publication(s) in Google Scholar
NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.
For research use only. We do not sell to patients.
- Purity: 98.81%
- CAS No.: 24292-60-2
- Formula: C21H28N7O17P3.2Na
- Molecular Weight:789.39
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) NADP disodium salt
More- J Adv Res. 2026 Apr 13:S2090-1232(26)00338-3. [Abstract]
- Cell Prolif. 2021 Apr;54(4):e13015. [Abstract]
- Cell Oncol (Dordr). 2023 Jun;46(3):761-776. [Abstract]
- Eur J Pharm Sci. 2023 Aug 1:187:106475. [Abstract]
- World J Microbiol Biotechnol. 2024 Oct 19;40(11):357. [Abstract]
- FASEB J. 2024 Jul 31;38(14):e23844. [Abstract]
- Insect Biochem Mol Biol. 2023 Jun:157:103958. [Abstract]
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
NADP disodium salt can impair folate metabolism and nucleotide biosynthesis in HCT116 cells at high concentrations, leading to the cessation of proliferation and prioritizing cell survival[1]. NADP disodium salt forms NAADP through IL-8-driven CD38 to mobilize Ca2+ and influence cell migration[2]. NADP disodium salt de novo synthesis mediated by NADK upregulation provides power for anabolic reaction and antioxidant system to promote breast cancer metastasis[3]. NADP disodium salt is upregulated in ROS generation mediated by hyperglycemia and IDPc induction, thereby protecting renal cells from oxidative stress[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 24292-60-2
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Appearance Solid
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Molecular Weight 789.39
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Formula C21H28N7O17P3.2Na
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O)[C@H]([N+]2=CC=CC(C(N)=O)=C2)O[C@@H]1COP([O-])(OP(OC[C@@H]3[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](N(C4=NC=N5)C=NC4=C5N)O3)(O)=O)=O.[2Na]
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Synonyms
Disodium NADP
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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J Adv Res
A "DUBTAC" targeting GLUL deubiquitination promotes BMSC osteogenic differentiation and implant osseointegration in type 2 diabetes. [Abstract]2026 Apr 13:S2090-1232(26)00338-3. PMID: 41980623 -
Cell Prolif
TSP50 promotes hepatocyte proliferation and tumour formation by activating glucose-6-phosphate dehydrogenase (G6PD). [Abstract]2021 Apr;54(4):e13015. PMID: 33630390 -
Cell Oncol (Dordr)
LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation. [Abstract]2023 Jun;46(3):761-776. PMID: 36913068 -
Eur J Pharm Sci
Investigating the relevance of CYP2J2 inhibition for drugs known to cause intermediate to high risk torsades de pointes. [Abstract]2023 Aug 1:187:106475. PMID: 37225005 -
World J Microbiol Biotechnol
Molecular insights and functional analysis of isocitrate dehydrogenase in two gram-negative pathogenic bacteria. [Abstract]2024 Oct 19;40(11):357. PMID: 39425873 -
FASEB J
Desaminotyrosine is a redox-active microbial metabolite that bolsters macrophage antimicrobial functions while attenuating IL-6 production. [Abstract]2024 Jul 31;38(14):e23844. PMID: 39046365 -
Insect Biochem Mol Biol
Development of an efficient insecticide substrate and inhibitor screening system of insect P450s using fission yeast. [Abstract]2023 Jun:157:103958. PMID: 37182814
Solvent & Solubility
H2O : 100 mg/mL (126.68 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
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- Deutsch - DE (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Chen L, et al. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nat Metab. 2019 Mar;1:404-415. Epub 2019 Mar 11. PMID: 31058257; PMCID: PMC6489125. [Content Brief]
[2]. Nam TS, et al. Interleukin-8 drives CD38 to form NAADP from NADP+ and NAAD in the endolysosomes to mobilize Ca2+ and effect cell migration. FASEB J. 2020 Sep;34(9):12565-12576. [Content Brief]
[3]. Ilter D, et al. NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Redox Biol. 2023 May;61:102627. [Content Brief]
[4]. Lee SH, et al. Upregulation of cytosolic NADP+-dependent isocitrate dehydrogenase by hyperglycemia protects renal cells against oxidative stress. Mol Cells. 2010 Feb 28;29(2):203-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2668 mL | 6.3340 mL | 12.6680 mL | 31.6700 mL |
| 5 mM | 0.2534 mL | 1.2668 mL | 2.5336 mL | 6.3340 mL | |
| 10 mM | 0.1267 mL | 0.6334 mL | 1.2668 mL | 3.1670 mL | |
| 15 mM | 0.0845 mL | 0.4223 mL | 0.8445 mL | 2.1113 mL | |
| 20 mM | 0.0633 mL | 0.3167 mL | 0.6334 mL | 1.5835 mL | |
| 25 mM | 0.0507 mL | 0.2534 mL | 0.5067 mL | 1.2668 mL | |
| 30 mM | 0.0422 mL | 0.2111 mL | 0.4223 mL | 1.0557 mL | |
| 40 mM | 0.0317 mL | 0.1584 mL | 0.3167 mL | 0.7918 mL | |
| 50 mM | 0.0253 mL | 0.1267 mL | 0.2534 mL | 0.6334 mL | |
| 60 mM | 0.0211 mL | 0.1056 mL | 0.2111 mL | 0.5278 mL | |
| 80 mM | 0.0158 mL | 0.0792 mL | 0.1584 mL | 0.3959 mL | |
| 100 mM | 0.0127 mL | 0.0633 mL | 0.1267 mL | 0.3167 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NADP disodium salt Related Classifications
HY-F0002A Related Classifications
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