1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Minoxidil sulfate

Minoxidil sulfate 

Cat. No.: HY-B1445 Purity: 99.56%
Handling Instructions

Minoxidil sulfate, a potent and ATP-sensitive K+ channel opener, is the sulfated metabolite of minoxidil. Minoxidil sulfate is considered as a vasodilator to promote hair growth in vivo.

For research use only. We do not sell to patients.

Minoxidil sulfate Chemical Structure

Minoxidil sulfate Chemical Structure

CAS No. : 83701-22-8

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10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Minoxidil sulfate, a potent and ATP-sensitive K+ channel opener, is the sulfated metabolite of minoxidil. Minoxidil sulfate is considered as a vasodilator to promote hair growth in vivo[1][3].

IC50 & Target

IC50: K channel[2]

In Vitro

Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration[2].
Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Rat brain microvascular endothelial cells (RBMECs)
Concentration: 0-100 μM
Incubation Time: 15 mins, 30 mins, 1 hour, 2 hours, 4 hours
Result: Induced RhoA activation and PKB phosphorylation at Ser-473.
Molecular Weight

289.31

Formula

C₉H₁₅N₅O₄S

CAS No.

83701-22-8

SMILES

NC1=NC(N2CCCCC2)=CC(N1OS(=O)(O)=O)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (864.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4565 mL 17.2825 mL 34.5650 mL
5 mM 0.6913 mL 3.4565 mL 6.9130 mL
10 mM 0.3456 mL 1.7282 mL 3.4565 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.19 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.19 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MinoxidilPotassium ChannelKcsAvasodilator,K channelmetabolitefolliclehair growthInhibitorinhibitorinhibit

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Minoxidil sulfate
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