1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Minoxidil sulfate

Minoxidil sulfate 

Cat. No.: HY-B1445 Purity: 99.56%
Handling Instructions

Minoxidil sulfate, a potent and ATP-sensitive K+ channel opener, is the sulfated metabolite of minoxidil. Minoxidil sulfate is considered as a vasodilator to promote hair growth in vivo.

For research use only. We do not sell to patients.

Minoxidil sulfate Chemical Structure

Minoxidil sulfate Chemical Structure

CAS No. : 83701-22-8

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Based on 1 publication(s) in Google Scholar

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Description

Minoxidil sulfate, a potent and ATP-sensitive K+ channel opener, is the sulfated metabolite of minoxidil. Minoxidil sulfate is considered as a vasodilator to promote hair growth in vivo[1][3].

IC50 & Target

IC50: K channel[2]

In Vitro

Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration[2].
Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS[2].

Western Blot Analysis[2]

Cell Line: Rat brain microvascular endothelial cells (RBMECs)
Concentration: 0-100 μM
Incubation Time: 15 mins, 30 mins, 1 hour, 2 hours, 4 hours
Result: Induced RhoA activation and PKB phosphorylation at Ser-473.
Molecular Weight

289.31

Formula

C₉H₁₅N₅O₄S

CAS No.

83701-22-8

SMILES

NC1=NC(N2CCCCC2)=CC(N1OS(=O)(O)=O)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

MinoxidilPotassium ChannelKcsAvasodilator,K channelmetabolitefolliclehair growthInhibitorinhibitorinhibit

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Minoxidil sulfate
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