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Cat. No.: HY-12753S1

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Debutyldronedarone-d₆ hydrochloride

(Synonyms: SR35021-dd₆ hydrochloride)

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Debutyldronedarone-d₆ hydrochloride (SR35021-d₆ hydrochloride) is the deuterated-labeled Debutyldronedarone (HY-12753). Debutyldronedarone (SR35021) is a Cytochrome P450 enzyme inhibitor and a Thyroid Hormone Receptor inhibitor, and it is a metabolite of Dronedarone (HY-A0016). Debutyldronedarone inhibits the binding of T3 to TRα1 and TRβ1. Debutyldronedarone reduces the incidence of reperfusion-induced ventricular fibrillation in anesthetized rats, while decreasing their heart rate and blood pressure. Debutyldronedarone can be used in studies related to ventricular fibrillation and atrial fibrillation.

For research use only. We do not sell to patients.

Purity: 99.27%
CAS No.: 1346598-70-6
Formula: C₂₇H₃₁D₆ClN₂O₅S
Molecular Weight:543.15

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Debutyldronedarone-d₆ hydrochloride Chemical Structure

CAS No.: 1346598-70-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Cytochrome P450 Isoforms :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 1346598-70-6
Unlabeled Cas 141626-35-9
Appearance Solid
Molecular Weight 543.15
Formula C₂₇H₃₁D₆ClN₂O₅S
Color White to off-white
SMILES

CS(=O)(NC1=CC=C(C2=C1)OC(CCCC)=C2C(C3=CC=C(C=C3)OC([2H])(C([2H])(C([2H])(NCCCC)[2H])[2H])[2H])=O)=O.Cl[H]
Synonyms

SR35021-dd₆ hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Therapeutic Goods Administration. Australian Public Assessment Report for Dronedarone Hydrochloride, submission PM-2008-3045-3, Australian Government Department of Health and Ageing, 2008.

[2]. Van Beeren HC, et al. Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence. Endocrinology. 2003 Feb;144(2):552-8. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Debutyldronedarone-d₆ hydrochloride

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Debutyldronedarone-d6 hydrochloride

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

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Calculators

Help & FAQs

Debutyldronedarone-d6 hydrochloride Related Classifications

HY-12753S1 Related Classifications

Debutyldronedarone-d₆ hydrochloride

Debutyldronedarone-d₆ hydrochloride Related Classifications