Tazarotenic acid (Synonyms: AGN 190299)

Cat. No.: HY-101108 Purity: 99.57%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.

For research use only. We do not sell to patients.

Tazarotenic acid Chemical Structure

CAS No. : 118292-41-4

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 198	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 198	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 820	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Other Forms of Tazarotenic acid:

Tazarotenic acid-d₆ Get quote

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Biological Activity
Purity & Documentation
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Description

In Vivo

Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats^[1]
.

	Male	Female	Male
Dose (mg kg^-1)	4.4	4.4	0.49
AUC (μg h mL^-1)	9.31 (2.14)	9.78 (1.36)	0.594 (0.95)
CL (mL min^-1 kg^-1)	7.96 (1.59)	7.62 (0.85)	14.0 (2.2)
k (h^-1)	0.562 (0.339)	0.820 (0.146)	0.741 (0.115)
T_1/2 (h)	1.64 (0.92)	0.86 (0.14)	0.95 (0.16)
V₀ (L kg^-1)	0.43 (0.05)	0.49 (0.06)	1.31 (1.15)
V_β (L kg^-1)	-	-	1.14 (0.09)
V_max (μg min^-1)	9.08 (2.89)	6.09 (1.22)	-
K_m (μg mL^-1)	7.09 (1.35)	5.12 (1.19)	-

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

323.41

Formula

C₁₉H₁₇NO₂S

CAS No.

118292-41-4

Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(C1=CC=C(C#CC2=CC=C3C(C(C)(C)CCS3)=C2)N=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (309.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0921 mL	15.4603 mL	30.9205 mL
5 mM	0.6184 mL	3.0921 mL	6.1841 mL
10 mM	0.3092 mL	1.5460 mL	3.0921 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.57%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (247 KB) HNMR (264 KB) LCMS (266 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0921 mL	15.4603 mL	30.9205 mL	77.3013 mL
	5 mM	0.6184 mL	3.0921 mL	6.1841 mL	15.4603 mL
	10 mM	0.3092 mL	1.5460 mL	3.0921 mL	7.7301 mL
	15 mM	0.2061 mL	1.0307 mL	2.0614 mL	5.1534 mL
	20 mM	0.1546 mL	0.7730 mL	1.5460 mL	3.8651 mL
	25 mM	0.1237 mL	0.6184 mL	1.2368 mL	3.0921 mL
	30 mM	0.1031 mL	0.5153 mL	1.0307 mL	2.5767 mL
	40 mM	0.0773 mL	0.3865 mL	0.7730 mL	1.9325 mL
	50 mM	0.0618 mL	0.3092 mL	0.6184 mL	1.5460 mL
	60 mM	0.0515 mL	0.2577 mL	0.5153 mL	1.2884 mL
	80 mM	0.0387 mL	0.1933 mL	0.3865 mL	0.9663 mL
	100 mM	0.0309 mL	0.1546 mL	0.3092 mL	0.7730 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tazarotenic acid118292-41-4AGN 190299AGN190299AGN-190299Inhibitorinhibitorinhibit

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