Tazarotenic acid
Based on 2 publication(s) in Google Scholar
Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.
For research use only. We do not sell to patients.
- Purity: 98.67%
- CAS No.: 118292-41-4
- Formula: C19H17NO2S
- Molecular Weight:323.41
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Metabolism/Protease Compound Library
HY-L012
-
FDA-Approved Drug Library
HY-L022
-
Drug Repurposing Compound Library
HY-L035
-
FDA Approved & Pharmacopeial Drug Library
HY-L066
-
Drug Metabolite Library
HY-L098
-
Human Metabolite Library
HY-L123
-
Off-patent Drug Library
HY-L141
-
MCE Bioactive Compound Library
HY-L001V
-
Drug Repurposing Compound Library Plus
HY-L035P
-
FDA-Approved Drug Library Plus
HY-L022P
-
FDA-Approved Drug Library Mini
HY-L022M
-
High-Throughput Bioactive Compound Library
HY-L205
-
Mass Spectrometry Human Metabolite Library
HY-L215
-
Alkyne Compound Library
HY-L258
Publications Citing Use of MedChemExpress (MCE) Tazarotenic acid
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| INS1(832/13) | EC50 |
6 nM
Compound: 38
|
Induction of glucose-stimulated insulin secretion in rat INS-1 832/13 cells incubated for 5 mins by ELISA assay
Induction of glucose-stimulated insulin secretion in rat INS-1 832/13 cells incubated for 5 mins by ELISA assay
|
[PMID: 33771587] |
.
| Male | Female | Male | |
| Dose (mg kg-1) | 4.4 | 4.4 | 0.49 |
| AUC (μg h mL-1) | 9.31 (2.14) | 9.78 (1.36) | 0.594 (0.95) |
| CL (mL min-1 kg-1) | 7.96 (1.59) | 7.62 (0.85) | 14.0 (2.2) |
| k (h-1) | 0.562 (0.339) | 0.820 (0.146) | 0.741 (0.115) |
| T1/2 (h) | 1.64 (0.92) | 0.86 (0.14) | 0.95 (0.16) |
| V0 (L kg-1) | 0.43 (0.05) | 0.49 (0.06) | 1.31 (1.15) |
| Vβ (L kg-1) | - | - | 1.14 (0.09) |
| Vmax (μg min-1) | 9.08 (2.89) | 6.09 (1.22) | - |
| Km (μg mL-1) | 7.09 (1.35) | 5.12 (1.19) | - |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 118292-41-4
-
Appearance Solid
-
Molecular Weight 323.41
-
Formula C19H17NO2S
-
Color Light yellow to light brown
-
SMILES
O=C(C1=CC=C(C#CC2=CC=C3C(C(C)(C)CCS3)=C2)N=C1)O
-
Synonyms
AGN 190299
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
Solvent & Solubility
DMSO : 100 mg/mL (309.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Chandraratna RA. Tazarotene--first of a new generation of receptor-selective retinoids. Br J Dermatol. 1996;135 Suppl 49:18-25. [Content Brief]
[2]. Hsyu PH, et al. Pharmacokinetics of a novel retinoid AGN 190168 and its metabolite AGN 190299 after intravenous administration of AGN 190168 to rats. Biopharm Drug Dispos. 1994;15(5):347-357. [Content Brief]
[3]. Abramovits W, et al. Treatment of warty dyskeratoma with tazarotenic acid. J Am Acad Dermatol. 2002;46(2 Suppl Case Reports):S4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0921 mL | 15.4603 mL | 30.9205 mL | 77.3013 mL |
| 5 mM | 0.6184 mL | 3.0921 mL | 6.1841 mL | 15.4603 mL | |
| 10 mM | 0.3092 mL | 1.5460 mL | 3.0921 mL | 7.7301 mL | |
| 15 mM | 0.2061 mL | 1.0307 mL | 2.0614 mL | 5.1534 mL | |
| 20 mM | 0.1546 mL | 0.7730 mL | 1.5460 mL | 3.8651 mL | |
| 25 mM | 0.1237 mL | 0.6184 mL | 1.2368 mL | 3.0921 mL | |
| 30 mM | 0.1031 mL | 0.5153 mL | 1.0307 mL | 2.5767 mL | |
| 40 mM | 0.0773 mL | 0.3865 mL | 0.7730 mL | 1.9325 mL | |
| 50 mM | 0.0618 mL | 0.3092 mL | 0.6184 mL | 1.5460 mL | |
| 60 mM | 0.0515 mL | 0.2577 mL | 0.5153 mL | 1.2884 mL | |
| 80 mM | 0.0387 mL | 0.1933 mL | 0.3865 mL | 0.9663 mL | |
| 100 mM | 0.0309 mL | 0.1546 mL | 0.3092 mL | 0.7730 mL |
Tazarotenic acid Related Classifications
HY-101108 Related Classifications
Powered by Bioz