1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. Tazarotenic acid

Tazarotenic acid (Synonyms: AGN 190299)

Cat. No.: HY-101108 Purity: 99.57%
Handling Instructions

Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.

For research use only. We do not sell to patients.

Tazarotenic acid Chemical Structure

Tazarotenic acid Chemical Structure

CAS No. : 118292-41-4

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5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
25 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 820 In-stock
Estimated Time of Arrival: December 31
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Description

Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma[1][2][3].

In Vivo

Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats[1]
.

Male Female Male
Dose (mg kg-1) 4.4 4.4 0.49
AUC (μg h mL-1) 9.31 (2.14) 9.78 (1.36) 0.594 (0.95)
CL (mL min-1 kg-1) 7.96 (1.59) 7.62 (0.85) 14.0 (2.2)
k (h-1) 0.562 (0.339) 0.820 (0.146) 0.741 (0.115)
T1/2 (h) 1.64 (0.92) 0.86 (0.14) 0.95 (0.16)
V0 (L kg-1) 0.43 (0.05) 0.49 (0.06) 1.31 (1.15)
Vβ (L kg-1) - - 1.14 (0.09)
Vmax (μg min-1) 9.08 (2.89) 6.09 (1.22) -
Km (μg mL-1) 7.09 (1.35) 5.12 (1.19) -

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

323.41

Formula

C19H17NO2S

CAS No.
SMILES

O=C(C1=CC=C(C#CC2=CC=C3C(C(C)(C)CCS3)=C2)N=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (309.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0921 mL 15.4603 mL 30.9205 mL
5 mM 0.6184 mL 3.0921 mL 6.1841 mL
10 mM 0.3092 mL 1.5460 mL 3.0921 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Tazarotenic acid
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