all-trans-Anhydro Retinol
Based on 1 Customer Validation
all-trans-Anhydro Retinol (Anhydrovitamin A) is an orally active degradation product formed by the dehydration of vitamin A alcohol and its esters under conditions such as acidic catalysis or hydroxylic solvents, with a biological activity only 0.4% of that of Vitamin A (HY-B1342). In rats, all-trans-Anhydro Retinol can be metabolized into hydroxy derivatives and their esters, but it cannot be converted into Vitamin A (HY-B1342) and has a low storage capacity in the body.
For research use only. We do not sell to patients.
- Purity: 99.02%
- CAS No.: 1224-78-8
- Formula: C20H28
- Molecular Weight:268.44
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Storage:
-80°C, protect from light, stored under nitrogen
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (approximately 7 weeks old) made Vitamin A (HY-B1342)-deficient by dietary restriction[1]
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Dosage:0.22 mg/0.1 mL
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Administration:Oral administration/subcutaneous injection; 6 days
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Result:Was metabolized into at least seven derivatives in the liver, including non-hydroxy, monohydroxy, and dihydroxy compounds with ester groups. The metabolites were poorly absorbed and stored, with no detectable levels remaining in the liver after 30 days.
Resulted in 26% of the liver storage by subcutaneous injection compared to oral administration. The growth-promoting activity was attributed to the in vivo-formed derivatives rather than conversion to vitamin A.
Chemical Information
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CAS No. 1224-78-8
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Appearance Solid
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Molecular Weight 268.44
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Formula C20H28
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Color Light yellow to yellow
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SMILES
CC1(C)CCC=C(C)/C1=C/C=C(C)/C=C/C=C(C)/C=C
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Synonyms
Anhydrovitamin A
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Structure Classification
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Initial Source
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light, stored under nitrogen
Solvent & Solubility
DMSO : 10 mg/mL (37.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. T N Varma, et al. The Utilization of Anhydrovitamin A by the Vitamin A-deficient Rat. Biochim Biophys Acta. 1965 Jun 15;104(1):71-7. [Content Brief]
[2]. T HIGUCHI, et al. Kinetics of Formation of Anhydrovitamin A From Vitamin A Alcohol and Its Acetate. J Am Pharm Assoc Am Pharm Assoc. 1959 Mar;48(3):155-61. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7252 mL | 18.6261 mL | 37.2523 mL | 93.1307 mL |
| 5 mM | 0.7450 mL | 3.7252 mL | 7.4505 mL | 18.6261 mL | |
| 10 mM | 0.3725 mL | 1.8626 mL | 3.7252 mL | 9.3131 mL | |
| 15 mM | 0.2483 mL | 1.2417 mL | 2.4835 mL | 6.2087 mL | |
| 20 mM | 0.1863 mL | 0.9313 mL | 1.8626 mL | 4.6565 mL | |
| 25 mM | 0.1490 mL | 0.7450 mL | 1.4901 mL | 3.7252 mL | |
| 30 mM | 0.1242 mL | 0.6209 mL | 1.2417 mL | 3.1044 mL |
all-trans-Anhydro Retinol Related Classifications
HY-N7495 Related Classifications
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