1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. SAICAR

SAICAR 

Cat. No.: HY-126585
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SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions.

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SAICAR Chemical Structure

SAICAR Chemical Structure

CAS No. : 3031-95-6

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Description

SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

SAICAR accumulation induces nuclear localization of PKM2. PKM2-SAICAR phosphorylates and activates Erk1/2, which in turn sensitizes PKM2 for SAICAR binding through phosphorylation. Additionally, PKM2-SAICAR was necessary to induce sustained Erk1/2 activation and mitogen-induced cell proliferation. SAICAR-PKM2 interaction is necessary and sufficient to induce H3 T11 and Erk1/2 phosphorylation[2].
Upon glucose starvation, cellular SAICAR concentration increases in an oscillatory manner and stimulates PKM2 activity in cancer cells. The SAICAR-PKM2 interaction also promotes cancer cell survival in glucose-limited conditions. In glucose-limited conditions, cells with higher SAICAR concentrations (adsl-kd cells or cells overexpressing PAICS) survive better while paics-kd cells died earlier than control-kd cells. SAICAR promotes cancer cell survival in glucose-limited conditions[3].

Molecular Weight

454.28

Formula

C₁₃H₁₉N₄O₁₂P

CAS No.

3031-95-6

SMILES

O=C(O)C[[email protected]@H](C(O)=O)NC(C1=C(N)N([[email protected]]2[[email protected]@H]([[email protected]@H]([[email protected]@H](COP(O)(O)=O)O2)O)O)C=N1)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SAICAREndogenous Metabolitepurinenucleotidebiosynthesismetaboliteglucose-limitedcancercellproliferationSAICAR-PKM2interactionsurvivalInhibitorinhibitorinhibit

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SAICAR
Cat. No.:
HY-126585
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