1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. mAChR
    Dopamine Receptor
    Drug Metabolite
  3. Clozapine N-oxide

Clozapine N-oxide 

Cat. No.: HY-17366 Purity: 99.98%
Handling Instructions

Clozapine (N-oxyde), un métabolite de la clozapine, est un agoniste des récepteurs concepteurs muscariniques humains (DREADDs). Clozapine est un antagoniste puissant de la dopamine. Clozapine est également un agoniste puissant et sélectif du récepteur muscarinique M4 (EC50=11 nM).

Clozapin (N-Oxid), ein Metabolit von Clozapin, ist ein Agonist für die humanen Muskarin-Designer-Rezeptoren (DREADDs). Clozapin ist ein starker Antagonist von Dopamin. Clozapin ist auch ein starker und selektiver Agonist am muskarinischen M4-Rezeptor (EC50=11 nM).

Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide specifically activates the DREADD receptor hM3Dq. Clozapine N-oxide can cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist.

For research use only. We do not sell to patients.

Clozapine N-oxide Chemical Structure

Clozapine N-oxide Chemical Structure

CAS No. : 34233-69-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg USD 420 In-stock
Estimated Time of Arrival: December 31
100 mg USD 672 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Clozapine N-oxide:

Top Publications Citing Use of Products

    Clozapine N-oxide purchased from MCE. Usage Cited in: Biol Psychiatry. 2017 May 1;81(9):737-747.

    c-fos immunoreactivity in the VTA 90 minutes after injections of 1 mg/kg Clozapine N-oxide (CNO).
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide specifically activates the DREADD receptor hM3Dq. Clozapine N-oxide can cross the blood-brain barrier[1][2][3]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[4][5].

    IC50 & Target

    Human muscarinic designer receptors (DREADDs)[1]

    In Vitro

    Clozapine N-oxide (CNO) can bind to non-DREADD receptors at concentrations required for DREADD activation, and undergoes reverse-metabolism to its parent compound clozapine, an atypical antipsychotic that acts at a variety of pharmacological targets and produces numerous physiological and behavioral effects[2].

    In Vivo

    After a single intraperitoneal (i.p.) injection of Clozapine N-oxide (1 mg/kg) into mice, Clozapine N-oxide (CNO) plasma levels peak at 15 min and are very low after 2 h. Despite the short plasma half-life of CNO in mice, the biological effects that have been described after acute treatment of DREADD-expressing experimental animals are usually much longer (6-10 h)[1].

    Molecular Weight

    342.82

    Formula

    C₁₈H₁₉ClN₄O

    CAS No.

    34233-69-7

    SMILES

    [O-][N+]1(C)CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)CC1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (291.70 mM)

    Methanol : ≥ 28.6 mg/mL (83.43 mM)

    H2O : 1 mg/mL (2.92 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9170 mL 14.5849 mL 29.1698 mL
    5 mM 0.5834 mL 2.9170 mL 5.8340 mL
    10 mM 0.2917 mL 1.4585 mL 2.9170 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (7.29 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (7.29 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.98%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Clozapine N-oxidemAChRDopamine ReceptorDrug MetaboliteMuscarinic acetylcholine receptorhM3DqBBBDREADDsClozapinemetaboliteG-proteinmuscarinic-M4Inhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product name:
    Clozapine N-oxide
    Cat. No.:
    HY-17366
    Quantity:
    MCE Japan Authorized Agent: