1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. N-Desmethyl Sildenafil

N-Desmethyl Sildenafil (Synonyms: Desmethylsildenafil; UK-103,320)

Cat. No.: HY-117605
Handling Instructions

N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor.

For research use only. We do not sell to patients.

N-Desmethyl Sildenafil Chemical Structure

N-Desmethyl Sildenafil Chemical Structure

CAS No. : 139755-82-1

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Description

N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2].

In Vitro

N-Desmethyl Sildenafil increases the amplitude of electroretinogram (ERG) recorded from the dark-adapted isolated rat retina, most probably through the enhancement of the photoreceptor cell response[1].
The formation of N-Desmethyl Sildenafil is examined using CYP3A supersomes co-expressing human P450 oxidoreductase and cytochrome b5. N-Desmethyl Sildenafil is catalyzed by CYP3A4, CYP3A5, and to a lesser extent by CYP3A7[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

460.55

Formula

C₂₁H₂₈N₆O₄S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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N-Desmethyl Sildenafil
Cat. No.:
HY-117605
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