139755-82-1
139755-82-1
Chemical Structure
N-Desmethyl Sildenafil
Synonym(s): Desmethylsildenafil; UK-103,320
- CAS No.: 139755-82-1
- Formula:C21H28N6O4S
- Molecular Weight:460.55
IUPAC Name: 5-(2-ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
InChIKey: UZTKBZXHEOVDRL-UHFFFAOYSA-N
SMILES: CCOC1=C(C=C(S(N2CCNCC2)(=O)=O)C=C1)C3=NC4=C(C(N3)=O)N(C)N=C4CCC
Biological Activity: N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2].
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N-Desmethyl Sildenafil | 99.60% | N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor. | ||||||||||||||||||||
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N-Desmethyl Sildenafil (Standard) | 98.82% | N-Desmethyl Sildenafil (Standard) is the analytical standard of N-Desmethyl Sildenafil. This product is intended for research and analytical applications. N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor. | ||||||||||||||||||||
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N-Desmethyl Sildenafil-d8 | N-Desmethyl Sildenafil-d8 is the deuterium labeled N-Desmethyl Sildenafil (HY-117605). N-Desmethyl Sildenafil is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor. | |||||||||||||||||||||
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References
- [1]. Péter Barabás, et al. Sildenafil, N-desmethyl-sildenafil and Zaprinast enhance photoreceptor response in the isolated rat retina. Neurochem Int. 2003 Nov;43(6):591-5. [Content Brief]
- [2]. Rikako Takahiro, et al. Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38(1):58-65. [Content Brief]
