1. Anti-infection
  2. Parasite
  3. Tizoxanide-d4 glucuronide

Tizoxanide-d4 glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum[1].

For research use only. We do not sell to patients.

Tizoxanide-d<sub>4</sub> glucuronide Chemical Structure

Tizoxanide-d4 glucuronide Chemical Structure

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Description

Tizoxanide-d4 glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum[1].

IC50 & Target

IC50: parasite[1]

In Vitro

Tizoxanide glucuronide (1-50 μg/ml; 46 hours) has effects on parasite development of Cryptosporidium parvum in HCT-8 cells. It exhibits MIC50 values of 2.2 μg/ml; 45.2 μg/ml; 11.7 μg/ml and 2.8 μg/ml in a sexual and sexual stages, sporozoite stage, asexual stages and sexual stages, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

445.39

Formula

C16H11D4N3O10S

SMILES

O=C(NC1=NC=C([N+]([O-])=O)S1)C2=C(O[C@H]3O[C@@H](C(O)=O)[C@H](O)[C@@H](O)[C@H]3O)C([2H])=C([2H])C([2H])=C2[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Tizoxanide-d4 glucuronide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Tizoxanide-d4 glucuronide
Cat. No.:
HY-136307S
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