1. Anti-infection
  2. Parasite
  3. Tizoxanide-D4 glucuronide

Tizoxanide-D4 glucuronide 

Cat. No.: HY-136307S
Handling Instructions

Tizoxanide glucuronide-D4 is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum.

For research use only. We do not sell to patients.

Tizoxanide-D4 glucuronide Chemical Structure

Tizoxanide-D4 glucuronide Chemical Structure

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Description

Tizoxanide glucuronide-D4 is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum[1].

IC50 & Target

IC50: parasite[1]

In Vitro

Tizoxanide glucuronide (1-50 μg/ml; 46 hours) has effects on parasite development of Cryptosporidium parvum in HCT-8 cells. It exhibits MIC50 values of 2.2 μg/ml; 45.2 μg/ml; 11.7 μg/ml and 2.8 μg/ml in a sexual and sexual stages, sporozoite stage, asexual stages and sexual stages, respectively[1].

Molecular Weight

445.39

Formula

C₁₆H₁₁D₄N₃O₁₀S

SMILES

O=C(NC1=NC=C([N+]([O-])=O)S1)C2=C(O[[email protected]]3O[[email protected]@H](C(O)=O)[[email protected]](O)[[email protected]@H](O)[[email protected]]3O)C([2H])=C([2H])C([2H])=C2[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Tizoxanide-D4 glucuronideParasiteHCT-8Cryptosporidium parvumsporozoiteasexualstageparasitesexual stageInhibitorinhibitorinhibit

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Product name:
Tizoxanide-D4 glucuronide
Cat. No.:
HY-136307S
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