1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. HOKU-81

HOKU-81 (Synonyms: 4-Hydroxytulobuterol)

Cat. No.: HY-50291 Purity: ≥95.0%
Handling Instructions

HOKU-81 (4-Hydroxytulobuterol) is one of the metabolites of Tulobuterol (HY-B1810). HOKU-81 is a potent and selective β2-adrenoceptor stimulant. HOKU-81 has bronchodilating effect.

For research use only. We do not sell to patients.

HOKU-81 Chemical Structure

HOKU-81 Chemical Structure

CAS No. : 58020-43-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 462 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

HOKU-81 (4-Hydroxytulobuterol) is one of the metabolites of Tulobuterol (HY-B1810). HOKU-81 is a potent and selective β2-adrenoceptor stimulant. HOKU-81 has bronchodilating effect[1][2].

IC50 & Target[1][2]

Beta-2 adrenergic receptor

 

In Vitro

HOKU-81 (4-Hydroxytulobuterol) is approximately 8 times more potent than tulobuterol, approximately twice as potent as salbutamol, and approximately as potent as isoprenaline in relaxing effect on the isolated tracheal smooth muscle preparation of guinea pigs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

243.73

Formula

C₁₂H₁₈ClNO₂

CAS No.

58020-43-2

SMILES

ClC1=C(C(O)CNC(C)(C)C)C=CC(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (205.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1029 mL 20.5145 mL 41.0290 mL
5 mM 0.8206 mL 4.1029 mL 8.2058 mL
10 mM 0.4103 mL 2.0515 mL 4.1029 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.26 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.26 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.26 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2

Keywords:

HOKU-814-HydroxytulobuterolHOKU81HOKU 81Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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HOKU-81
Cat. No.:
HY-50291
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