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GSK180 

Cat. No.: HY-112179
Handling Instructions

GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition.

For research use only. We do not sell to patients.

GSK180 Chemical Structure

GSK180 Chemical Structure

CAS No. : 1799725-26-0

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Description

GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition[1].

IC50 & Target

IC50: ~6 nM (KMO)[1]

In Vitro

GSK180 inhibits endogenous KMO activity in primary human hepatocytes (IC50=2.6 µM). GSK180 inhibits rat KMO slightly less potently than the human enzyme (IC50=7 µM)[1].

In Vivo

GSK180 is proper for i.v. administration[1].

Molecular Weight

276.07

Formula

C₁₀H₇Cl₂NO₄

CAS No.

1799725-26-0

SMILES

O=C(O)CCN1C(OC2=CC(Cl)=C(Cl)C=C12)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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