1799725-26-0
Chemical Structure
GSK180
- CAS No.: 1799725-26-0
- Formula:C10H7Cl2NO4
- Molecular Weight:276.07
IUPAC Name: 3-(5,6-dichloro-2-oxobenzo[d]oxazol-3(2H)-yl)propanoic acid
InChIKey: MIGAKMWKMLYGJX-UHFFFAOYSA-N
SMILES: O=C(O)CCN1C(OC2=CC(Cl)=C(Cl)C=C12)=O
Biological Activity: GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
GSK180 | 98.34% | GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
