6-Methyluracil (Synonyms: Pseudothymine)

Cat. No.: HY-Y1125 Purity: 98.45%: FAQs
Data Sheet SDS COA Handling Instructions

6-Methyluracil (Pseudothymine), a metabolite of Uracil, can be used as an indicator of acetoacetyl-CoA (AACoA) accumulation. 6-Methyluracil exhibits antiradiation effect in vivo.

For research use only. We do not sell to patients.

6-Methyluracil Chemical Structure

CAS No. : 626-48-2

Size	Price	Stock	Quantity
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
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5 g		Get quote

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Biological Activity
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Description

6-Methyluracil (Pseudothymine), a metabolite of Uracil, can be used as an indicator of acetoacetyl-CoA (AACoA) accumulation. 6-Methyluracil exhibits antiradiation effect in vivo^[1]^[2].

In Vivo

6-Methyluracil (50 mg/kg; a single i.p.) produces a pronounced radioprotective effect in BALB and SHK mice^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

126.11

Appearance

Solid

Formula

C₅H₆N₂O₂

CAS No.

626-48-2

SMILES

O=C1NC(C=C(C)N1)=O

Structure Classification

Others

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (396.48 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.9296 mL	39.6479 mL	79.2959 mL
5 mM	1.5859 mL	7.9296 mL	15.8592 mL
10 mM	0.7930 mL	3.9648 mL	7.9296 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 4.55 mg/mL (36.08 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (19.82 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (19.82 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 98.45%

Select Batch:

Data Sheet (273 KB) SDS (392 KB)

COA (249 KB) HNMR (81 KB) RP-HPLC (136 KB)

Handling Instructions (2659 KB)

References

[1]. Cromby CH, et, al. 6-Methyluracil excretion in 2-methylacetoacetyl-CoA thiolase deficiency and in two children with an unexplained recurrent ketoacidaemia. J Inherit Metab Dis. 1994;17(1):81-4. [Content Brief]

[2]. Taran IP, et, al. [The antiradiation action of 6-methyluracil]. Radiobiologiia. Mar-Apr 1993;33(2):285-90. [Content Brief]

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

6-Methyluracil626-48-2PseudothymineEndogenous MetabolitemetaboliteUracilindicatoracetoacetyl-CoAAACoAaccumulationantiradiationInhibitorinhibitorinhibit

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