1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. TP3011

TP3011 (Synonyms: CH0793011)

Cat. No.: HY-135845
Handling Instructions

TP3011 (CH0793011) is an active metabolite of CH-0793076 and is a potent topoisomerase I inhibitor equipotent as SN38. TP3011 is against cancer cell lines growth with IC50s at the range sub-nanomolar in vitro.

For research use only. We do not sell to patients.

TP3011 Chemical Structure

TP3011 Chemical Structure

CAS No. : 534605-74-8

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Description

TP3011 (CH0793011) is an active metabolite of CH-0793076 and is a potent topoisomerase I inhibitor equipotent as SN38[1]. TP3011 is against cancer cell lines growth with IC50s at the range sub-nanomolar in vitro[2].

IC50 & Target[1]

Topoisomerase I

 

In Vitro

TP3011 (0-100 nM; 72 hours) (compound 6c) inhibits cell proliferative activities against various human cancer cell lines, producing 50% inhibition (IC50) of cell growth of 0.85 nM; 8.5 nM; and 8.2 nM in HCT116, QG56, and NCI-H460 (NSCLC) cells, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: HCT116, QG56, and NCI-H460 (NSCLC) cells
Concentration: 0-100 nM
Incubation Time: 72 hours
Result: Was against human cancer cell lines, such as CRC and NSCLC cell lines.
Molecular Weight

474.51

Formula

C₂₆H₂₆N₄O₅

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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TP3011
Cat. No.:
HY-135845
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