534605-74-8
Chemical Structure
TP3011
Synonym(s): CH0793011
- CAS No.: 534605-74-8
- Formula:C26H26N4O5
- Molecular Weight:474.51
IUPAC Name: (S)-9-ethyl-9-hydroxy-1-pentyl-3,15-dihydro-1H,12H-pyrano[3'',4'':6',7']indolizino[2',1':5,6]pyrido[4,3,2-de]quinazoline-2,10,13(9H)-trione
InChIKey: SEFCGEILTGZHAO-SANMLTNESA-N
SMILES: O=C(N1CCCCC)NC2=C3C1=C(CN4C(C(COC([C@@]5(CC)O)=O)=C5C=C46)=O)C6=NC3=CC=C2
Biological Activity: TP3011 (CH0793011) is an active metabolite of CH-0793076 and is a potent topoisomerase I inhibitor equipotent as SN38[1]. TP3011 is against cancer cell lines growth with IC50s at the range sub-nanomolar in vitro[2].
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TP3011 | TP3011 (CH0793011) is an active metabolite of CH-0793076 and is a potent topoisomerase I inhibitor equipotent as SN38. TP3011 is against cancer cell lines growth with IC50s at the range sub-nanomolar in vitro. | |||||||||||||||||||||
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- [1]. Anthoney DA, et al. Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses.BMC Cancer. 2012 Nov 21;12:536. [Content Brief]
- [2]. Niizuma S, et al. Synthesis of new camptothecin analogs with improved antitumor activities.Bioorg Med Chem Lett. 2009 Apr 1;19(7):2018-21. [Content Brief]
Keywords
