2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Drug Metabolite Dopamine Receptor 5-HT Receptor
  4. Lurasidone metabolite 14326

Lurasidone metabolite 14326 is a minor active metabolite of Lurasidone (HY-B0032A) generated via metabolism by CYP3A4. Lurasidone metabolite 14326 shares similar receptor-binding properties with Lurasidone, acting as an antagonist of the dopamine D2 receptor (dopamine D2 receptor), an antagonist of the serotonin 5-HT2A and 5-HT7 receptors (5-HT2A and 5-HT7 receptor), and a partial agonist of the serotonin 5-HT1A receptor. Lurasidone metabolite 14326 can be used in the research of schizophrenia and bipolar depression.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Lurasidone metabolite 14326 hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Lurasidone metabolite 14326

Lurasidone metabolite 14326 Chemical Structure

CAS No. : 186204-33-1

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Other In-stock Forms of Lurasidone metabolite 14326:

Lurasidone metabolite 14326 Related Antibodies

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Description

Lurasidone metabolite 14326 is a minor active metabolite of Lurasidone (HY-B0032A) generated via metabolism by CYP3A4. Lurasidone metabolite 14326 shares similar receptor-binding properties with Lurasidone, acting as an antagonist of the dopamine D2 receptor (dopamine D2 receptor), an antagonist of the serotonin 5-HT2A and 5-HT7 receptors (5-HT2A and 5-HT7 receptor), and a partial agonist of the serotonin 5-HT1A receptor. Lurasidone metabolite 14326 can be used in the research of schizophrenia and bipolar depression[1].

IC50 & Target[1]

D2 Receptor

 

5-HT2A Receptor

 

5-HT7 Receptor

 

5-HT1A Receptor

 

In Vitro

Lurasidone metabolite 14326 exhibits receptor-binding pharmacodynamic activity similar to that of Lurasidone in assays using rat, guinea pig and human recombinant cell receptors, but its exposure (concentration) in humans is extremely low[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lurasidone metabolite 14326 Related Antibodies
Molecular Weight

508.68

Formula

C28H36N4O3S
CAS No.
SMILES

O=C([C@]([C@@H]1C[C@H](O)[C@H]2C1)([H])[C@]2([H])C3=O)N3C[C@H]4[C@H](CN(CC5)CCN5C6=NSC7=C6C=CC=C7)CCCC4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lurasidone metabolite 14326 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lurasidone metabolite 14326186204-33-1Lurasidone metabolite14326Lurasidone metabolite-14326Drug MetaboliteDopamine Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorguinea pighuman recombinant cell-based receptor assaysschizophreniaratbipolar depressionInhibitorinhibitorinhibit

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