2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Sphinganine 1-phosphate

Sphinganine 1-phosphate  (Synonyms: D-erythro-Dihydrosphingosine 1-phosphate)

Cat. No.: HY-113116 Purity: ≥99.0%
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Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes.

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Sphinganine 1-phosphate Chemical Structure

Sphinganine 1-phosphate Chemical Structure

CAS No. : 19794-97-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Sphinganine 1-phosphate:

Sphinganine 1-phosphate Related Antibodies

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Description

Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Sphinganine 1-phosphate (S1P) is a potent signaling molecule involved in cell stress responses, cancer, angiogenesis and lymphocyte trafficking. Sphinganine 1-phosphate functions primarily by activating a subgroup of the endothelial differentiation gene (EDG) family of G-protein coupled cell surface receptors. Sphinganine 1-phosphate has opposite effects in the regulation of cell metabolism. Sphinganine 1-phosphate regulates skeletal muscle differentiation and regeneration[1].
Sphinganine 1-phosphate (S1P) is involved in cancer. Sphinganine 1-phosphate regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival[1].
Sphinganine-1-Phosphate (1 μM) phosphorylates ERK MAPK, Akt, and HSP27 and induces HSP27 in human renal endothelial cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sphinganine 1-phosphate Related Antibodies

Cell Viability Assay[2]

Cell Line: Human renal endothelial cells or human kidney proximal tubule (HK-2) cells
Concentration: 1 μM
Incubation Time: 2 or 4 hours
Result: Induced HSP27 mRNA in cultured human renal endothelial cells.
Phosphorylated ERK MAPK and AKT in human renal endothelial cells in a time-dependent manner.
Phosphorylated and induced HSP27.
In Vivo

Sphinganine 1-phosphate can enhance wound healing in diabetic mice[1]. Sphinganine 1-phosphate provides renal and hepatic protection after liver ischemia and reperfusion (IR) injury in mice through selective activation of S1P1 receptors and pertussis toxin-sensitive G-proteins with subsequent activation of ERK and Akt. Sphinganine 1-phosphate (administered 0.1 mg/kg i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion) protects against hepatic and renal injury after liver IR[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (20-25 g)[2]
Dosage: 0.1 mg/kg
Administration: Administered i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion
Result: The plasma level of alanine aminotransferase (ALT) and Creatinine (Cr) was 80±6 U/L and 0.46±0.05 mg/dL, respectively.
The increases in ALT (7474±557 U/L) and Cr (0.55±0.05 mg/dL) were significantly suppressed at 24 h after reperfusion in mice treated with 0.1 mg/kg i.v. before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion.
Molecular Weight

381.49

Formula

C18H40NO5P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)COP(O)(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

0.3 M NaOH : 4 mg/mL (10.49 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6213 mL 13.1065 mL 26.2130 mL
5 mM 0.5243 mL 2.6213 mL 5.2426 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (239 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.3 M NaOH 1 mM 2.6213 mL 13.1065 mL 26.2130 mL 65.5325 mL
5 mM 0.5243 mL 2.6213 mL 5.2426 mL 13.1065 mL
10 mM 0.2621 mL 1.3107 mL 2.6213 mL 6.5533 mL
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Sphinganine 1-phosphate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sphinganine 1-phosphate19794-97-9D-erythro-Dihydrosphingosine 1-phosphateEndogenous MetabolitesphingolipidmetabolitecellmigrationdifferentiationsurvivalphysiologicalAktendothelialextracellularsignal-regulatedkinasenecrosisInhibitorinhibitorinhibit

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