1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Glucosidase
    PPAR
  3. Norathyriol

Norathyriol (Synonyms: Mangiferitin)

Cat. No.: HY-N1029
Handling Instructions

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

For research use only. We do not sell to patients.

Norathyriol Chemical Structure

Norathyriol Chemical Structure

CAS No. : 3542-72-1

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Description

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

IC50 & Target[2]

PPARα

92.8 μM (IC50)

PPARβ

102.4 μM (IC50)

PPARγ

153.5 μM (IC50)

In Vitro

Norathyriol (1-25 µM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest[3].
Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cells[3] Cell Growth Assay WB

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Mouse skin epidermal JB6 P+ cells
Concentration: 0, 1, 10, or 25 µM
Incubation Time: 24 or 72 hours
Result: Inhibited cell growth in a dose- as well as time-dependent manner but does not cause cell death.

Western Blot Analysis[3]

Cell Line: JB6 P+ cells
Concentration: 0, 1, 10, or 25 µM
Incubation Time: 2 hours
Result: Inhibited UVB-induced phosphorylation of ERKs and p90RSK.
In Vivo

Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety[1].
Norathyriol (0.92, 1.85 and 3.7 mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Kunming mice weighing 18-22 g[4]
Dosage: 0.92, 1.85 and 3.7 mg/kg
Administration: Administered intragastrically; twice daily for five times
Result: The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.
Molecular Weight

260.20

Formula

C₁₃H₈O₆

CAS No.
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Storage

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References
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Norathyriol
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