1. Metabolic Enzyme/Protease
  2. Glucosidase
  3. Voglibose

Voglibose 

Cat. No.: HY-B0025 Purity: ≥98.0%
Handling Instructions

Voglibose is an N-substituted derivative of valiolamine, excellent inhibitory activity against α-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia.

For research use only. We do not sell to patients.

Voglibose Chemical Structure

Voglibose Chemical Structure

CAS No. : 83480-29-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 84 In-stock
Estimated Time of Arrival: December 31
50 mg USD 76 In-stock
Estimated Time of Arrival: December 31
100 mg USD 114 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Voglibose is an N-substituted derivative of valiolamine, excellent inhibitory activity against α-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia. Target: α-glucosidases glibose can inhibit the intestinal α-glucosidases, which are responsible for the digestion of disaccharides such as maltose and sucrose, including maltase and sucrase. The Ki values of Voglibose for sucrase and maltase are about 106and 105 times smaller than the Km values for sucrose and maltose [1]. Voglibose (0.2 mg/kg) completely inhibits the insulin response to sucrose in rats. Voglibose (0.2 mg/kg) reduces the carbohydrate-induced increase in blood glucose in rats. Voglibose (0.2 mg/kg) reduces the carbohydrate-induced increase in blood glucose without causing sustained hypoglycemia in both normal and neonatal streptozotocin-induced diabetic rats [2]. Voglibose (0.001%) treatment increases GLP-1 secretion (Voglibose alone, 1.6-fold; Alogliptin plus Voglibose, 1.5-fold), while it decreases plasma glucose-dependent insulinotropic polypeptide (GIP) (Voglibose alone, 30%; Alogliptin plus voglibose, 29%) in prediabetic db/db mice after 3 weeks. Voglibose (0.001%) treatment decreases plasma DPP-4 activity by 15% in prediabetic db/db mice. Voglibose (0.001%) treatment increases plasma insulin by 1.8-fold and decreases plasma glucagon by 8% in prediabetic db/db mice [3].

Clinical Trial
Molecular Weight

267.28

Formula

C₁₀H₂₁NO₇

CAS No.

83480-29-9

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (374.14 mM; Need ultrasonic)

DMSO : 100 mg/mL (374.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7414 mL 18.7070 mL 37.4139 mL
5 mM 0.7483 mL 3.7414 mL 7.4828 mL
10 mM 0.3741 mL 1.8707 mL 3.7414 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

VogliboseGlucosidaseInhibitorinhibitorinhibit

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Product Name:
Voglibose
Cat. No.:
HY-B0025
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