Art. -Nr.: HY-14860

1-Deoxynojirimycin

(Synonyms: Duvoglustat)

7 Cited Publications

Kundenbewertung

Based on 7 publication(s) in Google Scholar

1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features.

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Reinheit: 98.0%
CAS. Nr.: 19130-96-2
Formel: C₆H₁₃NO₄
Molecular Weight:163.17

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

1-Deoxynojirimycin Chemical Structure

CAS. Nr.: 19130-96-2

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vivo
- Clinical Trial
Chemical Information
Publications (7)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle PI3K Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>1000 μM Compound: DNJ	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 21036045]
A549	IC₅₀	>10 μM Compound: 1	Cytotoxicity against human A549 cells measured after 48 hrs by MTT assay Cytotoxicity against human A549 cells measured after 48 hrs by MTT assay	[PMID: 33979163]
BGC-823	IC₅₀	>10 μM Compound: 1	Cytotoxicity against human BGC-823 cells measured after 48 hrs by MTT assay Cytotoxicity against human BGC-823 cells measured after 48 hrs by MTT assay	[PMID: 33979163]
Caco-2	IC₅₀	0.06 μM Compound: 1, DNJ	Inhibition of maltase in human Caco-2 cell model system after 2 hrs Inhibition of maltase in human Caco-2 cell model system after 2 hrs	[PMID: 18595718]
HCC1937	IC₅₀	>10 μM Compound: 1	Cytotoxicity against human HCC1937 cells measured after 48 hrs by MTT assay Cytotoxicity against human HCC1937 cells measured after 48 hrs by MTT assay	[PMID: 33979163]
HCT-116	IC₅₀	>10 μM Compound: 1	Cytotoxicity against human HCT-116 cells measured after 48 hrs by MTT assay Cytotoxicity against human HCT-116 cells measured after 48 hrs by MTT assay	[PMID: 33979163]
HEK293	IC₅₀	>100 μM Compound: dNM, 1-deoxynojirimycin	Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 18343126]
HEK293	IC₅₀	>100 μM Compound: dNM, 1-deoxynojirimycin	Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 18343126]
HepG2	IC₅₀	>10 μM Compound: 1	Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay	[PMID: 33979163]
HUVEC	IC₅₀	2 μM Compound: 2a	Growth inhibition of HUVEC cells by MTT assay Growth inhibition of HUVEC cells by MTT assay	[PMID: 18166456]
MCF7	IC₅₀	>10 μM Compound: 1	Cytotoxicity against human MCF7 cells measured after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells measured after 48 hrs by MTT assay	[PMID: 33979163]
MOLT-4	CC₅₀	>100 mg/mL Compound: 1	Concentration giving 50% inhibition of growth of mock-infected MOLT-4 cells Concentration giving 50% inhibition of growth of mock-infected MOLT-4 cells	[PMID: 7608901]
MOLT-4	EC₅₀	>100 mg/mL Compound: 1	Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MOLT-4 cells Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MOLT-4 cells	[PMID: 7608901]
MS-1	IC₅₀	2 μM Compound: 2a	Growth inhibition of mouse MS1 cells by MTT assay Growth inhibition of mouse MS1 cells by MTT assay	[PMID: 18166456]
MT4	CC₅₀	>100 mg/mL Compound: 1	Concentration giving 50% inhibition of growth of mock-infected MT-4 cells Concentration giving 50% inhibition of growth of mock-infected MT-4 cells	[PMID: 7608901]
MT4	EC₅₀	>100 mg/mL Compound: 1	Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MT-4 cells Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MT-4 cells	[PMID: 7608901]
T-cell	IC₅₀	25.62 μM Compound: DNM	Inhibition of CD4 expression in human CD4+ T cells Inhibition of CD4 expression in human CD4+ T cells	[PMID: 22101135]

In Vivo

1-Deoxynojirimycin (Duvoglustat) (20-80 mg/kg; i.v.; daily for four weeks) shows anti-obesity effect ^[3].
1-Deoxynojirimycin significantly improves insulin sensitivity via activating insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

db/db mice^[3]
Dosage:

20, 40, 80 mg/kg
Administration:

Intravenously; daily for four weeks
Result:

Significantly reduced body weight, blood glucose and serum insulin levels; Improved glucose tolerance and insulin tolerance.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 19130-96-2
Appearance Solid
Molecular Weight 163.17
Formel C₆H₁₃NO₄
Color White to off-white
SMILES

O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O
Synonyms

Duvoglustat
Structure Classification
- Alkaloids
- Piperidine Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (7)

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Journal Impact Factor

Adv Healthc Mater

Regulation of T Cell Glycosylation by MXene/β-TCP Nanocomposite for Enhanced Mandibular Bone Regeneration. [Abstract]

2025 Mar;14(6):e2404015. PMID: 39764719
Int J Biol Macromol

Site-specific analysis and functional characterization of N-linked glycosylation for β-Klotho protein. [Abstract]

2025 Feb:289:138846. PMID: 39701265
J Biol Chem

Golgi α-Mannosidases Regulate Cell Surface N-Glycan Type and Ectodomain Shedding of the Transmembrane Protease Corin. [Abstract]

2023 Oct;299(10):105211. PMID: 37660903
Environ Microbiol

Interaction between the cell walls of microalgal host and fungal carbohydrate-activate enzymes is essential for the pathogenic parasitism process. [Abstract]

2021 Sep;23(9):5114-5130. PMID: 33723900
Exp Cell Res

Blood coagulation factor VIII D1241E polymorphism leads to a weak malectin interaction and reduction of factor VIII posttranslational modification and secretion. [Abstract]

2020 Dec 1;397(1):112334. PMID: 33144078
bioRxiv

2026 May 15.
Authorea

2025 Jan 05.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 125 mg/mL (766.07 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.1286 mL

30.6429 mL

61.2858 mL

5 mM

1.2257 mL

6.1286 mL

12.2572 mL

10 mM

0.6129 mL

3.0643 mL

6.1286 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (612.86 mM); Clear solution; Need ultrasonic

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21(11). pii: E1600. [Content Brief]

[2]. Chaluntorn Vichasilp,et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232

[3]. Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20(12):21700-14. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	6.1286 mL	30.6429 mL	61.2858 mL	153.2144 mL
	5 mM	1.2257 mL	6.1286 mL	12.2572 mL	30.6429 mL
	10 mM	0.6129 mL	3.0643 mL	6.1286 mL	15.3214 mL
	15 mM	0.4086 mL	2.0429 mL	4.0857 mL	10.2143 mL
	20 mM	0.3064 mL	1.5321 mL	3.0643 mL	7.6607 mL
	25 mM	0.2451 mL	1.2257 mL	2.4514 mL	6.1286 mL
	30 mM	0.2043 mL	1.0214 mL	2.0429 mL	5.1071 mL
	40 mM	0.1532 mL	0.7661 mL	1.5321 mL	3.8304 mL
	50 mM	0.1226 mL	0.6129 mL	1.2257 mL	3.0643 mL
	60 mM	0.1021 mL	0.5107 mL	1.0214 mL	2.5536 mL
	80 mM	0.0766 mL	0.3830 mL	0.7661 mL	1.9152 mL
	100 mM	0.0613 mL	0.3064 mL	0.6129 mL	1.5321 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

1-Deoxynojirimycin

7 Cited Publications

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1-Deoxynojirimycin

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Publications Citing Use of MedChemExpress (MCE) 1-Deoxynojirimycin

Alle PI3K Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (7)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

1-Deoxynojirimycin Related Classifications

HY-14860 Related Classifications