2. Metabolic Enzyme/Protease PI3K/Akt/mTOR
  3. Glucosidase PI3K
  4. 1-Deoxynojirimycin

1-Deoxynojirimycin  (Synonyms: Duvoglustat)

Cat. No.: HY-14860 Purity: ≥98.0%
COA Handling Instructions

1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features.

For research use only. We do not sell to patients.

1-Deoxynojirimycin Chemical Structure

1-Deoxynojirimycin Chemical Structure

CAS No. : 19130-96-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 79 In-stock
Solution
10 mM * 1 mL in Water USD 79 In-stock
Solid
5 mg USD 72 In-stock
10 mg USD 94 In-stock
25 mg USD 198 In-stock
50 mg USD 369 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of 1-Deoxynojirimycin:

1-Deoxynojirimycin Related Antibodies

Top Publications Citing Use of Products

View All PI3K Isoform Specific Products:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • Biological Activity

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  • References

  • Customer Review

Description

1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].

In Vivo

1-Deoxynojirimycin (Duvoglustat) (20-80 mg/kg; i.v.; daily for four weeks) shows anti-obesity effect [3].
? 1-Deoxynojirimycin significantly improves insulin sensitivity via activating insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: db/db mice[3]
Dosage: 20, 40, 80 mg/kg
Administration: Intravenously; daily for four weeks
Result: Significantly reduced body weight, blood glucose and serum insulin levels; Improved glucose tolerance and insulin tolerance.
Clinical Trial
Molecular Weight

163.17

Appearance

Solid

Formula

C6H13NO4
CAS No.
SMILES

O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 34 mg/mL (208.37 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.1286 mL 30.6429 mL 61.2858 mL
5 mM 1.2257 mL 6.1286 mL 12.2572 mL
10 mM 0.6129 mL 3.0643 mL 6.1286 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (612.86 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (249 KB) HNMR (244 KB)

Handling Instructions (2659 KB)
References
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1-Deoxynojirimycin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

1-Deoxynojirimycin19130-96-2DuvoglustatGlucosidasePI3KPhosphoinositide 3-kinasepostprandialbloodglucosediabetesantihyperglycemicanti-obesityantiviralinsulinInhibitorinhibitorinhibit

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