Deoxymannojirimycin hydrochloride
Based on 1 publication(s) in Google Scholar
Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor. Deoxymannojirimycin hydrochloride has antiviral activity against HIV‐1 strains . Deoxymannojirimycin hydrochloride increases high mannose structures. Deoxymannojirimycin hydrochloride can be used for the study of liver cancer and colon cancer.
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- CAS No.: 84444-90-6
- Formula: C6H13NO4
- Molecular Weight:163.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Deoxymannojirimycin hydrochloride
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Biological Activity
Deoxymannojirimycin (2 mM; 24 h) hydrochloride inhibits Golgi α-mannosidase I and leads to an increase in high mannose structures in P815 and EL-4 cells[1].
Deoxymannojirimycin (4-5 days) hydrochloride shows antiviral efficacy against mutant HIV-1 strains in CEM cell cultures, with EC50 values ranging between 90 and 155 μM[2].
Deoxymannojirimycin (100-250 μM) hydrochloride potentiates the antiviral efficacy of CBAs (HHA and GNA) against wild-type HIV-1 replication in CEM cell cultures[2].
Deoxymannojirimycin (1 mM; 8 h) hydrochloride induces the activation and up-regulation of key molecules of ER stress-UPR, such as GRP78/Bip and XBP1, in human hepatocarcinoma 7721 cells[3].
Deoxymannojirimycin (150 μM; 15 h) hydrochloride causes the accumulation of Man8GlcNAc2 on 97-kDa HMG-CoA reductase in UT-1 cells[4].
Deoxymannojirimycin (2 mM) hydrochloride completely inhibits α-mannosidase I activity in both differentiated and undifferentiated HT-29 cells[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 84444-90-6
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Molecular Weight 163.17
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Formula C6H13NO4
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SMILES
OC[C@@H]1[C@H]([C@@H]([C@@H](CN1)O)O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Healthc Mater
Regulation of T Cell Glycosylation by MXene/β-TCP Nanocomposite for Enhanced Mandibular Bone Regeneration. [Abstract]2025 Mar;14(6):e2404015. PMID: 39764719
Purity & Documentation
References
[1]. Bagriaçik EU, et al. Glycosylation of native MHC class Ia molecules is required for recognition by allogeneic cytotoxic T lymphocytes. Glycobiology. 1996 Jun;6(4):413-21. [Content Brief]
[2]. Balzarini J. The alpha(1,2)-mannosidase I inhibitor Deoxymannojirimycin potentiates the antiviral activity of carbohydrate-binding agents against wild-type and mutant HIV-1 strains containing glycan deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4. [Content Brief]
[3]. Lu Y, et al. Deoxymannojirimycin, the alpha1,2-mannosidase inhibitor, induced cellular endoplasmic reticulum stress in human hepatocarcinoma cell 7721. Biochem Biophys Res Commun. 2006 May 26;344(1):221-5. [Content Brief]
[4]. Bischoff J, et al. The use of Deoxymannojirimycin to evaluate the role of various alpha-mannosidases in oligosaccharide processing in intact cells. J Biol Chem. 1986 Apr 5;261(10):4766-74. [Content Brief]
[5]. Ogier-Denis E, et al. Dual effect of Deoxymannojirimycin on the mannose uptake and on the N-glycan processing of the human colon cancer cell line HT-29. J Biol Chem. 1990 Apr 5;265(10):5366-9. [Content Brief]
[6]. F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)