84444-90-6
Chemical Structure
Deoxymannojirimycin hydrochloride
- CAS No.: 84444-90-6
- Formula:C6H13NO4
- Molecular Weight:163.17
IUPAC Name: (2R,3R,4R,5R)-2-(hydroxymethyl)piperidine-3,4,5-triol
InChIKey: LXBIFEVIBLOUGU-KVTDHHQDSA-N
SMILES: OC[C@@H]1[C@H]([C@@H]([C@@H](CN1)O)O)O
Biological Activity: Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor. Deoxymannojirimycin hydrochloride has antiviral activity against HIV‐1 strains . Deoxymannojirimycin hydrochloride increases high mannose structures. Deoxymannojirimycin hydrochloride can be used for the study of liver cancer and colon cancer[1][2][3][4][5][6].
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Deoxymannojirimycin hydrochloride | Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor. Deoxymannojirimycin hydrochloride has antiviral activity against HIV‐1 strains . Deoxymannojirimycin hydrochloride increases high mannose structures. Deoxymannojirimycin hydrochloride can be used for the study of liver cancer and colon cancer. | |||||||||||||||||||||
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- [1]. Bagriaçik EU, et al. Glycosylation of native MHC class Ia molecules is required for recognition by allogeneic cytotoxic T lymphocytes. Glycobiology. 1996 Jun;6(4):413-21. [Content Brief]
- [2]. Balzarini J. The alpha(1,2)-mannosidase I inhibitor Deoxymannojirimycin potentiates the antiviral activity of carbohydrate-binding agents against wild-type and mutant HIV-1 strains containing glycan deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4. [Content Brief]
- [3]. Lu Y, et al. Deoxymannojirimycin, the alpha1,2-mannosidase inhibitor, induced cellular endoplasmic reticulum stress in human hepatocarcinoma cell 7721. Biochem Biophys Res Commun. 2006 May 26;344(1):221-5. [Content Brief]
- [4]. Bischoff J, et al. The use of Deoxymannojirimycin to evaluate the role of various alpha-mannosidases in oligosaccharide processing in intact cells. J Biol Chem. 1986 Apr 5;261(10):4766-74. [Content Brief]
- [5]. Ogier-Denis E, et al. Dual effect of Deoxymannojirimycin on the mannose uptake and on the N-glycan processing of the human colon cancer cell line HT-29. J Biol Chem. 1990 Apr 5;265(10):5366-9. [Content Brief]
- [6]. F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98. [Content Brief]
Keywords
