1. Metabolic Enzyme/Protease
    Anti-infection
    Cell Cycle/DNA Damage
  2. Endogenous Metabolite
    Enterovirus
    HCV
    Topoisomerase
    SARS-CoV
  3. NHC-diphosphate

NHC-diphosphate 

Cat. No.: HY-135867D
Handling Instructions

NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV)  and hepatitis C virus (HCV).

For research use only. We do not sell to patients.

NHC-diphosphate Chemical Structure

NHC-diphosphate Chemical Structure

CAS No. : 39023-73-9

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Description

NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV)  and hepatitis C virus (HCV)[1].

In Vitro

Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.
Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP; HY-135867D) can be observed, while NHC-triphosphate remains the most abundant metabolite.[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

419.18

Formula

C₉H₁₅N₃O₁₂P₂

CAS No.

39023-73-9

SMILES

O[[email protected]]([[email protected]@H]1O)[[email protected]@](N(C=C/C2=N\O)C(N2)=O)([H])O[[email protected]@H]1CO[P](O[P](O)(O)=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O : 160 mg/mL (381.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3856 mL 11.9281 mL 23.8561 mL
5 mM 0.4771 mL 2.3856 mL 4.7712 mL
10 mM 0.2386 mL 1.1928 mL 2.3856 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NHC-diphosphateEndogenous MetaboliteEnterovirusHCVTopoisomeraseSARS-CoVRhinovirusHRVHRVsHEVHEVsHepatitis C virusSARS coronavirusintracellularmetaboliteVEEVCHIKVInhibitorinhibitorinhibit

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NHC-diphosphate
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HY-135867D
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